Peter Sorger, PhD

Otto Krayer Professor of Systems Pharmacology, Harvard Medical School
Molecular analysis of kinetochore-microtubule attachment in budding yeast.
Authors: Authors: He X, Rines DR, Espelin CW, Sorger PK.
Cell
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Kinetochores distinguish GTP from GDP forms of the microtubule lattice.
Authors: Authors: Severin FF, Sorger PK, Hyman AA.
Nature
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Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer.
Authors: Authors: Färkkilä A, Gulhan DC, Casado J, Jacobson CA, Nguyen H, Kochupurakkal B, Maliga Z, Yapp C, Chen YA, Schapiro D, Zhou Y, Graham JR, Dezube BJ, Munster P, Santagata S, Garcia E, Rodig S, Lako A, Chowdhury D, Shapiro GI, Matulonis UA, Park PJ, Hautaniemi S, Sorger PK, Swisher EM, D'Andrea AD, Konstantinopoulos PA.
Nat Commun
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Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity.
Authors: Authors: Hafner M, Mills CE, Subramanian K, Chen C, Chung M, Boswell SA, Everley RA, Liu C, Walmsley CS, Juric D, Sorger PK.
Cell Chem Biol
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Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition.
Authors: Authors: Jones DS, Jenney AP, Joughin BA, Sorger PK, Lauffenburger DA.
Sci Signal
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Cyclic Immunofluorescence (CycIF), A Highly Multiplexed Method for Single-cell Imaging.
Authors: Authors: Lin JR, Fallahi-Sichani M, Chen JY, Sorger PK.
Curr Protoc Chem Biol
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LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures.
Authors: Authors: Duan Q, Flynn C, Niepel M, Hafner M, Muhlich JL, Fernandez NF, Rouillard AD, Tan CM, Chen EY, Golub TR, Sorger PK, Subramanian A, Ma'ayan A.
Nucleic Acids Res
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Properties of cell death models calibrated and compared using Bayesian approaches.
Authors: Authors: Eydgahi H, Chen WW, Muhlich JL, Vitkup D, Tsitsiklis JN, Sorger PK.
Mol Syst Biol
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Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics.
Authors: Authors: Orth JD, Kohler RH, Foijer F, Sorger PK, Weissleder R, Mitchison TJ.
Cancer Res
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Towards a rigorous assessment of systems biology models: the DREAM3 challenges.
Authors: Authors: Prill RJ, Marbach D, Saez-Rodriguez J, Sorger PK, Alexopoulos LG, Xue X, Clarke ND, Altan-Bonnet G, Stolovitzky G.
PLoS One
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