Peter Sorger, PhD

Otto Krayer Professor of Systems Pharmacology, Harvard Medical School
Clathrin cubes: an extreme variant of the normal cage.
Authors: Authors: Sorger PK, Crowther RA, Finch JT, Pearse BM.
J Cell Biol
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Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism.
Authors: Authors: Schauer NJ, Liu X, Magin RS, Doherty LM, Chan WC, Ficarro SB, Hu W, Roberts RM, Iacob RE, Stolte B, Giacomelli AO, Perera S, McKay K, Boswell SA, Weisberg EL, Ray A, Chauhan D, Dhe-Paganon S, Anderson KC, Griffin JD, Li J, Hahn WC, Sorger PK, Engen JR, Stegmaier K, Marto JA, Buhrlage SJ.
Sci Rep
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A Multi-center Study on the Reproducibility of Drug-Response Assays in Mammalian Cell Lines.
Authors: Authors: Niepel M, Hafner M, Mills CE, Subramanian K, Williams EH, Chung M, Gaudio B, Barrette AM, Stern AD, Hu B, Korkola JE, Gray JW, Birtwistle MR, Heiser LM, Sorger PK.
Cell Syst
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A High Content Screen in Macrophages Identifies Small Molecule Modulators of STING-IRF3 and NFkB Signaling.
Authors: Authors: Koch PD, Miller HR, Yu G, Tallarico JA, Sorger PK, Wang Y, Feng Y, Thomas JR, Ross NT, Mitchison T.
ACS Chem Biol
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Structure-guided development of covalent TAK1 inhibitors.
Authors: Authors: Tan L, Gurbani D, Weisberg EL, Hunter JC, Li L, Jones DS, Ficarro SB, Mowafy S, Tam CP, Rao S, Du G, Griffin JD, Sorger PK, Marto JA, Westover KD, Gray NS.
Bioorg Med Chem
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Failure analysis of clinical trials to test the amyloid hypothesis.
Authors: Authors: Hyman BT, Sorger P.
Ann Neurol
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Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo.
Authors: Authors: Thurber GM, Yang KS, Reiner T, Kohler RH, Sorger P, Mitchison T, Weissleder R.
Nat Commun
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Comparing signaling networks between normal and transformed hepatocytes using discrete logical models.
Authors: Authors: Saez-Rodriguez J, Alexopoulos LG, Zhang M, Morris MK, Lauffenburger DA, Sorger PK.
Cancer Res
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Cytokine-associated drug toxicity in human hepatocytes is associated with signaling network dysregulation.
Authors: Authors: Cosgrove BD, Alexopoulos LG, Hang TC, Hendriks BS, Sorger PK, Griffith LG, Lauffenburger DA.
Mol Biosyst
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Flexible informatics for linking experimental data to mathematical models via DataRail.
Authors: Authors: Saez-Rodriguez J, Goldsipe A, Muhlich J, Alexopoulos LG, Millard B, Lauffenburger DA, Sorger PK.
Bioinformatics
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