Peter Sorger, PhD

Otto Krayer Professor of Systems Pharmacology, Harvard Medical School
Comparing signaling networks between normal and transformed hepatocytes using discrete logical models.
Authors: Authors: Saez-Rodriguez J, Alexopoulos LG, Zhang M, Morris MK, Lauffenburger DA, Sorger PK.
Cancer Res
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Cytokine-associated drug toxicity in human hepatocytes is associated with signaling network dysregulation.
Authors: Authors: Cosgrove BD, Alexopoulos LG, Hang TC, Hendriks BS, Sorger PK, Griffith LG, Lauffenburger DA.
Mol Biosyst
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Flexible informatics for linking experimental data to mathematical models via DataRail.
Authors: Authors: Saez-Rodriguez J, Goldsipe A, Muhlich J, Alexopoulos LG, Millard B, Lauffenburger DA, Sorger PK.
Bioinformatics
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The response of human epithelial cells to TNF involves an inducible autocrine cascade.
Authors: Authors: Janes KA, Gaudet S, Albeck JG, Nielsen UB, Lauffenburger DA, Sorger PK.
Cell
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Chromosome segregation and genomic stability.
Authors: Authors: Draviam VM, Xie S, Sorger PK.
Curr Opin Genet Dev
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Molecular analysis of kinetochore-microtubule attachment in budding yeast.
Authors: Authors: He X, Rines DR, Espelin CW, Sorger PK.
Cell
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Kinetochores distinguish GTP from GDP forms of the microtubule lattice.
Authors: Authors: Severin FF, Sorger PK, Hyman AA.
Nature
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Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer.
Authors: Authors: Färkkilä A, Gulhan DC, Casado J, Jacobson CA, Nguyen H, Kochupurakkal B, Maliga Z, Yapp C, Chen YA, Schapiro D, Zhou Y, Graham JR, Dezube BJ, Munster P, Santagata S, Garcia E, Rodig S, Lako A, Chowdhury D, Shapiro GI, Matulonis UA, Park PJ, Hautaniemi S, Sorger PK, Swisher EM, D'Andrea AD, Konstantinopoulos PA.
Nat Commun
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Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity.
Authors: Authors: Hafner M, Mills CE, Subramanian K, Chen C, Chung M, Boswell SA, Everley RA, Liu C, Walmsley CS, Juric D, Sorger PK.
Cell Chem Biol
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Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition.
Authors: Authors: Jones DS, Jenney AP, Joughin BA, Sorger PK, Lauffenburger DA.
Sci Signal
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