Stephen Blacklow

Stephen Blacklow, MD, PhD

Gustavus Adolphus Pfeiffer Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School

Dr. Blacklow is currently the Gustavus Adolphus Pfeiffer Professor and Chair of the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School, and a member of the Department of Cancer Biology at the Dana Farber Cancer Institute.

Research led by Dr. Blacklow’s team has shown how cell surface receptors can convey a developmental signal directly from one contacting cell surface to the next and then from the membrane to the nucleus. He has elucidated key molecular events in Notch signal transduction, a conserved cell-cell communication system that influences cell fate decisions in all metazoan organisms, and that is frequently hijacked as an oncogenic driver in human leukemia. His research on the Notch pathway has led to the development of new investigational therapies for hematologic malignancies such as T cell acute lymphocytic leukemia (ALL).

Dr. Blacklow was a recipient of the National Cancer Institute’s prestigious Outstanding Investigator Award in 2017, and elected to the Association of American Physicians in 2018. Dr. Blacklow directed the MD-PhD Program in Basic and Translational Sciences at Harvard Medical School and has served on Advisory Committees for pre-clinical departments, graduate programs, and MD-PhD programs at several major research universities and institutions, including Stanford, the University of Pennsylvania, and the Memorial Sloan Kettering Cancer Center.

Dr. Blacklow received his MD and PhD degrees from Harvard University in 1991, completed his residency in Clinical Pathology at Brigham and Women’s Hospital, and carried out postdoctoral research at the Whitehead Institute with Dr. Peter S. Kim.

A Spatiotemporal Map of Co-Receptor Signaling Networks Underlying B Cell Activation
Authors: Authors: Katherine J Susa , Gary A Bradshaw, Robyn J Eisert, Charlotte M Schilling, Marian Kalocsay, Stephen C Blacklow, Andrew C Kruse
CellPress
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Tetraspanins: structure, dynamics, and principles of partner-protein recognition
Authors: Authors: Katherine J. Susa, Andrew C. Kruse, and Stephen C. Blacklow
CellPress
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Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2.
Authors: Authors: LaRochelle JR, Fodor M, Ellegast JM, Liu X, Vemulapalli V, Mohseni M, Stams T, Buhrlage SJ, Stegmaier K, LaMarche MJ, Acker MG, Blacklow SC.
Bioorg Med Chem
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Complete hematologic response of early T-cell progenitor acute lymphoblastic leukemia to the ?-secretase inhibitor BMS-906024: genetic and epigenetic findings in an outlier case.
Authors: Authors: Knoechel B, Bhatt A, Pan L, Pedamallu CS, Severson E, Gutierrez A, Dorfman DM, Kuo FC, Kluk M, Kung AL, Zweidler-McKay P, Meyerson M, Blacklow SC, DeAngelo DJ, Aster JC.
Cold Spring Harb Mol Case Stud
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Conformational locking upon cooperative assembly of notch transcription complexes.
Authors: Authors: Choi SH, Wales TE, Nam Y, O'Donovan DJ, Sliz P, Engen JR, Blacklow SC.
Structure
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Mechanistic insights into Notch receptor signaling from structural and biochemical studies.
Authors: Authors: Kovall RA, Blacklow SC.
Curr Top Dev Biol
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c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma.
Authors: Authors: Weng AP, Millholland JM, Yashiro-Ohtani Y, Arcangeli ML, Lau A, Wai C, Del Bianco C, Rodriguez CG, Sai H, Tobias J, Li Y, Wolfe MS, Shachaf C, Felsher D, Blacklow SC, Pear WS, Aster JC.
Genes Dev
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Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
Authors: Authors: Weng AP, Ferrando AA, Lee W, Morris JP, Silverman LB, Sanchez-Irizarry C, Blacklow SC, Look AT, Aster JC.
Science
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Folding determinants of LDL receptor type A modules.
Authors: Authors: Koduri V, Blacklow SC.
Biochemistry
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Neuroimaging findings in patients on immunosuppressive therapy: experience with tacrolimus toxicity.
Authors: Authors: Appignani BA, Bhadelia RA, Blacklow SC, Wang AK, Roland SF, Freeman RB.
AJR Am J Roentgenol
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