Tim Mitchison

Timothy Mitchison, PhD

Hasib Sabbagh Professor of Systems Biology, Harvard Medical School

Tim Mitchison, PhD, received his BA in Biochemistry from Oxford University, England, in 1980, and his PhD from the University of California, San Francisco (UCSF), in Biochemistry and Biophysics in 1984, where he worked with Professor Marc Kirschner. At this time he discovered the dynamic instability of microtubules. Later he worked at the National Institute for Medical Research in London. In 1987 he returned to San Francisco to become an Assistant Professor at UCSF. In 1997 he moved to the Cell Biology Department at Harvard Medical School where he co-founded the Institute for Chemistry and Cell Biology.

Dr. Mitchison was a founding member of the HMS Department of Systems Biology, which started in 2004. He is currently Deputy Chair of the department, and Co-director of the Systems Biology PhD Program. He was elected a Fellow of the Royal Society in 1997, and member of the American Association of Arts and Sciences in 2008. In 2010 he served as President of the American Society of Cell Biology. And most recently in 2014 he became a member of the National Academy of Sciences.

Rapid de-localization of actin leading edge components with BDM treatment.
Authors: Authors: Yarrow JC, Lechler T, Li R, Mitchison TJ.
BMC Cell Biol
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Single-molecule speckle analysis of actin filament turnover in lamellipodia.
Authors: Authors: Watanabe N, Mitchison TJ.
Science
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Regulated actin cytoskeleton assembly at filopodium tips controls their extension and retraction.
Authors: Authors: Mallavarapu A, Mitchison T.
J Cell Biol
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Purification and assay of gamma tubulin ring complex.
Authors: Authors: Zheng Y, Wong ML, Alberts B, Mitchison T.
Methods Enzymol
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Catastrophic revelations about Op18/stathmin.
Authors: Authors: Belmont L, Mitchison T, Deacon HW.
Trends Biochem Sci
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Microtubule flux in mitosis is independent of chromosomes, centrosomes, and antiparallel microtubules.
Authors: Authors: Sawin KE, Mitchison TJ.
Mol Biol Cell
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The rate of actin-based motility of intracellular Listeria monocytogenes equals the rate of actin polymerization.
Authors: Authors: Theriot JA, Mitchison TJ, Tilney LG, Portnoy DA.
Nature
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Cell biology. Motoring in the spindle.
Authors: Authors: Sawin K, Mitchison T.
Nature
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Direct observation of steady-state microtubule dynamics.
Authors: Authors: Kristofferson D, Mitchison T, Kirschner M.
J Cell Biol
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Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models.
Authors: Authors: Silva MC, Ferguson FM, Cai Q, Donovan KA, Nandi G, Patnaik D, Zhang T, Huang HT, Lucente DE, Dickerson BC, Mitchison TJ, Fischer ES, Gray NS, Haggarty SJ.
Elife
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