Tim Mitchison

Timothy Mitchison, PhD

Hasib Sabbagh Professor of Systems Biology, Harvard Medical School

Tim Mitchison, PhD, received his BA in Biochemistry from Oxford University, England, in 1980, and his PhD from the University of California, San Francisco (UCSF), in Biochemistry and Biophysics in 1984, where he worked with Professor Marc Kirschner. At this time he discovered the dynamic instability of microtubules. Later he worked at the National Institute for Medical Research in London. In 1987 he returned to San Francisco to become an Assistant Professor at UCSF. In 1997 he moved to the Cell Biology Department at Harvard Medical School where he co-founded the Institute for Chemistry and Cell Biology.

Dr. Mitchison was a founding member of the HMS Department of Systems Biology, which started in 2004. He is currently Deputy Chair of the department, and Co-director of the Systems Biology PhD Program. He was elected a Fellow of the Royal Society in 1997, and member of the American Association of Arts and Sciences in 2008. In 2010 he served as President of the American Society of Cell Biology. And most recently in 2014 he became a member of the National Academy of Sciences.

Functional analysis of a human homologue of the Drosophila actin binding protein anillin suggests a role in cytokinesis.
Authors: Authors: Oegema K, Savoian MS, Mitchison TJ, Field CM.
J Cell Biol
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Interaction of human Arp2/3 complex and the Listeria monocytogenes ActA protein in actin filament nucleation.
Authors: Authors: Welch MD, Rosenblatt J, Skoble J, Portnoy DA, Mitchison TJ.
Science
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XCTK2: a kinesin-related protein that promotes mitotic spindle assembly in Xenopus laevis egg extracts.
Authors: Authors: Walczak CE, Verma S, Mitchison TJ.
J Cell Biol
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Mutations in the kinesin-like protein Eg5 disrupting localization to the mitotic spindle.
Authors: Authors: Sawin KE, Mitchison TJ.
Proc Natl Acad Sci U S A
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Poleward kinetochore fiber movement occurs during both metaphase and anaphase-A in newt lung cell mitosis.
Authors: Authors: Mitchison TJ, Salmon ED.
J Cell Biol
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Two different microtubule-based motor activities with opposite polarities in kinetochores.
Authors: Authors: Hyman AA, Mitchison TJ.
Nature
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Polewards chromosome movement driven by microtubule depolymerization in vitro.
Authors: Authors: Koshland DE, Mitchison TJ, Kirschner MW.
Nature
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Dynamic instability of microtubule growth.
Authors: Authors: Mitchison T, Kirschner M.
Nature
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Assembly of Spindles and Asters in Xenopus Egg Extracts.
Authors: Authors: Field CM, Mitchison TJ.
Cold Spring Harb Protoc
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Physical basis of large microtubule aster growth.
Authors: Authors: Ishihara K, Korolev KS, Mitchison TJ.
Elife
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