Tim Mitchison

Timothy Mitchison, PhD

Hasib Sabbagh Professor of Systems Biology, Harvard Medical School

Tim Mitchison, PhD, received his BA in Biochemistry from Oxford University, England, in 1980, and his PhD from the University of California, San Francisco (UCSF), in Biochemistry and Biophysics in 1984, where he worked with Professor Marc Kirschner. At this time he discovered the dynamic instability of microtubules. Later he worked at the National Institute for Medical Research in London. In 1987 he returned to San Francisco to become an Assistant Professor at UCSF. In 1997 he moved to the Cell Biology Department at Harvard Medical School where he co-founded the Institute for Chemistry and Cell Biology.

Dr. Mitchison was a founding member of the HMS Department of Systems Biology, which started in 2004. He is currently Deputy Chair of the department, and Co-director of the Systems Biology PhD Program. He was elected a Fellow of the Royal Society in 1997, and member of the American Association of Arts and Sciences in 2008. In 2010 he served as President of the American Society of Cell Biology. And most recently in 2014 he became a member of the National Academy of Sciences.

Small-molecule screening and profiling by using automated microscopy.
Authors: Authors: Mitchison TJ.
Chembiochem
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Chemical genetics to identify NFAT inhibitors: potential of targeting calcium mobilization in immunosuppression.
Authors: Authors: Venkatesh N, Feng Y, DeDecker B, Yacono P, Golan D, Mitchison T, McKeon F.
Proc Natl Acad Sci U S A
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Phenotypic screening of small molecule libraries by high throughput cell imaging.
Authors: Authors: Yarrow JC, Feng Y, Perlman ZE, Kirchhausen T, Mitchison TJ.
Comb Chem High Throughput Screen
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A small-molecule inhibitor of skeletal muscle myosin II.
Authors: Authors: Cheung A, Dantzig JA, Hollingworth S, Baylor SM, Goldman YE, Mitchison TJ, Straight AF.
Nat Cell Biol
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Allele-specific activators and inhibitors for kinesin.
Authors: Authors: Kapoor TM, Mitchison TJ.
Proc Natl Acad Sci U S A
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Purification and assay of a septin complex from Drosophila embryos.
Authors: Authors: Oegema K, Desai A, Wong ML, Mitchison TJ, Field CM.
Methods Enzymol
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A purified Drosophila septin complex forms filaments and exhibits GTPase activity.
Authors: Authors: Field CM, al-Awar O, Rosenblatt J, Wong ML, Alberts B, Mitchison TJ.
J Cell Biol
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Actin-dependent motile forces and cell motility.
Authors: Authors: Cramer LP, Mitchison TJ, Theriot JA.
Curr Opin Cell Biol
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Self-organization of polymer-motor systems in the cytoskeleton.
Authors: Authors: Mitchison TJ.
Philos Trans R Soc Lond B Biol Sci
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Modulation of microtubule stability by kinetochores in vitro.
Authors: Authors: Hyman AA, Mitchison TJ.
J Cell Biol
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