Tim Mitchison

Timothy Mitchison, PhD

Hasib Sabbagh Professor of Systems Biology, Harvard Medical School

Tim Mitchison, PhD, received his BA in Biochemistry from Oxford University, England, in 1980, and his PhD from the University of California, San Francisco (UCSF), in Biochemistry and Biophysics in 1984, where he worked with Professor Marc Kirschner. At this time he discovered the dynamic instability of microtubules. Later he worked at the National Institute for Medical Research in London. In 1987 he returned to San Francisco to become an Assistant Professor at UCSF. In 1997 he moved to the Cell Biology Department at Harvard Medical School where he co-founded the Institute for Chemistry and Cell Biology.

Dr. Mitchison was a founding member of the HMS Department of Systems Biology, which started in 2004. He is currently Deputy Chair of the department, and Co-director of the Systems Biology PhD Program. He was elected a Fellow of the Royal Society in 1997, and member of the American Association of Arts and Sciences in 2008. In 2010 he served as President of the American Society of Cell Biology. And most recently in 2014 he became a member of the National Academy of Sciences.

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish.
Authors: Authors: Niethammer P, Grabher C, Look AT, Mitchison TJ.
Nature
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Implications of a poroelastic cytoplasm for the dynamics of animal cell shape.
Authors: Authors: Mitchison TJ, Charras GT, Mahadevan L.
Semin Cell Dev Biol
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NuSAP, a mitotic RanGTP target that stabilizes and cross-links microtubules.
Authors: Authors: Ribbeck K, Groen AC, Santarella R, Bohnsack MT, Raemaekers T, Köcher T, Gentzel M, Görlich D, Wilm M, Carmeliet G, Mitchison TJ, Ellenberg J, Hoenger A, Mattaj IW.
Mol Biol Cell
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The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles.
Authors: Authors: Miyamoto DT, Perlman ZE, Burbank KS, Groen AC, Mitchison TJ.
J Cell Biol
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Colloid surface chemistry critically affects multiple particle tracking measurements of biomaterials.
Authors: Authors: Valentine MT, Perlman ZE, Gardel ML, Shin JH, Matsudaira P, Mitchison TJ, Weitz DA.
Biophys J
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Exo1: a new chemical inhibitor of the exocytic pathway.
Authors: Authors: Feng Y, Yu S, Lasell TK, Jadhav AP, Macia E, Chardin P, Melancon P, Roth M, Mitchison T, Kirchhausen T.
Proc Natl Acad Sci U S A
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Probing cell division with "chemical genetics".
Authors: Authors: Mitchison TJ.
Harvey Lect
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Spatial control of actin polymerization during neutrophil chemotaxis.
Authors: Authors: Weiner OD, Servant G, Welch MD, Mitchison TJ, Sedat JW, Bourne HR.
Nat Cell Biol
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Purification of cytoskeletal proteins using peptide antibodies.
Authors: Authors: Field CM, Oegema K, Zheng Y, Mitchison TJ, Walczak CE.
Methods Enzymol
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Identification of a protein that interacts with tubulin dimers and increases the catastrophe rate of microtubules.
Authors: Authors: Belmont LD, Mitchison TJ.
Cell
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