Tim Mitchison

Timothy Mitchison, PhD

Hasib Sabbagh Professor of Systems Biology, Harvard Medical School

Tim Mitchison, PhD, received his BA in Biochemistry from Oxford University, England, in 1980, and his PhD from the University of California, San Francisco (UCSF), in Biochemistry and Biophysics in 1984, where he worked with Professor Marc Kirschner. At this time he discovered the dynamic instability of microtubules. Later he worked at the National Institute for Medical Research in London. In 1987 he returned to San Francisco to become an Assistant Professor at UCSF. In 1997 he moved to the Cell Biology Department at Harvard Medical School where he co-founded the Institute for Chemistry and Cell Biology.

Dr. Mitchison was a founding member of the HMS Department of Systems Biology, which started in 2004. He is currently Deputy Chair of the department, and Co-director of the Systems Biology PhD Program. He was elected a Fellow of the Royal Society in 1997, and member of the American Association of Arts and Sciences in 2008. In 2010 he served as President of the American Society of Cell Biology. And most recently in 2014 he became a member of the National Academy of Sciences.

Actin microfilament dynamics in locomoting cells.
Authors: Authors: Theriot JA, Mitchison TJ.
Nature
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Cytoskeletal dynamics and nerve growth.
Authors: Authors: Mitchison T, Kirschner M.
Neuron
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Assembly properties of fluorescein-labeled tubulin in vitro before and after fluorescence bleaching.
Authors: Authors: Leslie RJ, Saxton WM, Mitchison TJ, Neighbors B, Salmon ED, McIntosh JR.
J Cell Biol
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Site occupancy calibration of taxane pharmacology in live cells and tissues.
Authors: Authors: Pineda JJ, Miller MA, Song Y, Kuhn H, Mikula H, Tallapragada N, Weissleder R, Mitchison TJ.
Proc Natl Acad Sci U S A
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Chromosomal passenger complex hydrodynamics suggests chaperoning of the inactive state by nucleoplasmin/nucleophosmin.
Authors: Authors: Hanley ML, Yoo TY, Sonnett M, Needleman DJ, Mitchison TJ.
Mol Biol Cell
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Spindle-to-cortex communication in cleaving, polyspermic Xenopus eggs.
Authors: Authors: Field CM, Groen AC, Nguyen PA, Mitchison TJ.
Mol Biol Cell
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Electron microscopy of microtubule cytoskeleton assembly in vitro.
Authors: Authors: Coughlin M, Groen AC, Mitchison TJ.
Methods Mol Biol
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Graduate education. Interdisciplinary graduate training in teaching labs.
Authors: Authors: Vale RD, DeRisi J, Phillips R, Mullins RD, Waterman C, Mitchison TJ.
Science
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Rapid induction of apoptosis during Kinesin-5 inhibitor-induced mitotic arrest in HL60 cells.
Authors: Authors: Tang Y, Orth JD, Xie T, Mitchison TJ.
Cancer Lett
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Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly.
Authors: Authors: Huang HC, Shi J, Orth JD, Mitchison TJ.
Cancer Cell
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