Tim Mitchison

Timothy Mitchison, PhD

Hasib Sabbagh Professor of Systems Biology, Harvard Medical School

Tim Mitchison, PhD, received his BA in Biochemistry from Oxford University, England, in 1980, and his PhD from the University of California, San Francisco (UCSF), in Biochemistry and Biophysics in 1984, where he worked with Professor Marc Kirschner. At this time he discovered the dynamic instability of microtubules. Later he worked at the National Institute for Medical Research in London. In 1987 he returned to San Francisco to become an Assistant Professor at UCSF. In 1997 he moved to the Cell Biology Department at Harvard Medical School where he co-founded the Institute for Chemistry and Cell Biology.

Dr. Mitchison was a founding member of the HMS Department of Systems Biology, which started in 2004. He is currently Deputy Chair of the department, and Co-director of the Systems Biology PhD Program. He was elected a Fellow of the Royal Society in 1997, and member of the American Association of Arts and Sciences in 2008. In 2010 he served as President of the American Society of Cell Biology. And most recently in 2014 he became a member of the National Academy of Sciences.

Mechanism and function of poleward flux in Xenopus extract meiotic spindles.
Authors: Authors: Mitchison TJ.
Philos Trans R Soc Lond B Biol Sci
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A high-throughput cell migration assay using scratch wound healing, a comparison of image-based readout methods.
Authors: Authors: Yarrow JC, Perlman ZE, Westwood NJ, Mitchison TJ.
BMC Biotechnol
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An inner centromere protein that stimulates the microtubule depolymerizing activity of a KinI kinesin.
Authors: Authors: Ohi R, Coughlin ML, Lane WS, Mitchison TJ.
Dev Cell
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EB1-microtubule interactions in Xenopus egg extracts: role of EB1 in microtubule stabilization and mechanisms of targeting to microtubules.
Authors: Authors: Tirnauer JS, Grego S, Salmon ED, Mitchison TJ.
Mol Biol Cell
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A switch in microtubule dynamics at the onset of anaphase B in the mitotic spindle of Schizosaccharomyces pombe.
Authors: Authors: Mallavarapu A, Sawin K, Mitchison T.
Curr Biol
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Anaphase A chromosome movement and poleward spindle microtubule flux occur At similar rates in Xenopus extract spindles.
Authors: Authors: Desai A, Maddox PS, Mitchison TJ, Salmon ED.
J Cell Biol
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Investigation of the mechanism of retraction of the cell margin and rearward flow of nodules during mitotic cell rounding.
Authors: Authors: Cramer LP, Mitchison TJ.
Mol Biol Cell
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A heterodimeric coiled-coil protein required for mitotic chromosome condensation in vitro.
Authors: Authors: Hirano T, Mitchison TJ.
Cell
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Comparison of actin and cell surface dynamics in motile fibroblasts.
Authors: Authors: Theriot JA, Mitchison TJ.
J Cell Biol
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Preparation of modified tubulins.
Authors: Authors: Hyman A, Drechsel D, Kellogg D, Salser S, Sawin K, Steffen P, Wordeman L, Mitchison T.
Methods Enzymol
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