Tim Mitchison

Timothy Mitchison, PhD

Hasib Sabbagh Professor of Systems Biology, Harvard Medical School

Tim Mitchison, PhD, received his BA in Biochemistry from Oxford University, England, in 1980, and his PhD from the University of California, San Francisco (UCSF), in Biochemistry and Biophysics in 1984, where he worked with Professor Marc Kirschner. At this time he discovered the dynamic instability of microtubules. Later he worked at the National Institute for Medical Research in London. In 1987 he returned to San Francisco to become an Assistant Professor at UCSF. In 1997 he moved to the Cell Biology Department at Harvard Medical School where he co-founded the Institute for Chemistry and Cell Biology.

Dr. Mitchison was a founding member of the HMS Department of Systems Biology, which started in 2004. He is currently Deputy Chair of the department, and Co-director of the Systems Biology PhD Program. He was elected a Fellow of the Royal Society in 1997, and member of the American Association of Arts and Sciences in 2008. In 2010 he served as President of the American Society of Cell Biology. And most recently in 2014 he became a member of the National Academy of Sciences.

Fast microtubule dynamics in meiotic spindles measured by single molecule imaging: evidence that the spindle environment does not stabilize microtubules.
Authors: Authors: Needleman DJ, Groen A, Ohi R, Maresca T, Mirny L, Mitchison T.
Mol Biol Cell
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Spindle fusion requires dynein-mediated sliding of oppositely oriented microtubules.
Authors: Authors: Gatlin JC, Matov A, Groen AC, Needleman DJ, Maresca TJ, Danuser G, Mitchison TJ, Salmon ED.
Curr Biol
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Polar stimulation and constrained cell migration in microfluidic channels.
Authors: Authors: Irimia D, Charras G, Agrawal N, Mitchison T, Toner M.
Lab Chip
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Small molecules in an RNAi world.
Authors: Authors: Eggert US, Field CM, Mitchison TJ.
Mol Biosyst
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Eg5 causes elongation of meiotic spindles when flux-associated microtubule depolymerization is blocked.
Authors: Authors: Shirasu-Hiza M, Perlman ZE, Wittmann T, Karsenti E, Mitchison TJ.
Curr Biol
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A novel action of histone deacetylase inhibitors in a protein aggresome disease model.
Authors: Authors: Corcoran LJ, Mitchison TJ, Liu Q.
Curr Biol
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Dynamics of the mitotic spindle--potential therapeutic targets.
Authors: Authors: Miyamoto DT, Perlman ZE, Mitchison TJ, Shirasu-Hiza M.
Prog Cell Cycle Res
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Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL.
Authors: Authors: Degterev A, Lugovskoy A, Cardone M, Mulley B, Wagner G, Mitchison T, Yuan J.
Nat Cell Biol
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The use of Xenopus egg extracts to study mitotic spindle assembly and function in vitro.
Authors: Authors: Desai A, Murray A, Mitchison TJ, Walczak CE.
Methods Cell Biol
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Rappaport rules: cleavage furrow induction in animal cells.
Authors: Authors: Oegema K, Mitchison TJ.
Proc Natl Acad Sci U S A
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