Tim Mitchison

Timothy Mitchison, PhD

Hasib Sabbagh Professor of Systems Biology, Harvard Medical School

Tim Mitchison, PhD, received his BA in Biochemistry from Oxford University, England, in 1980, and his PhD from the University of California, San Francisco (UCSF), in Biochemistry and Biophysics in 1984, where he worked with Professor Marc Kirschner. At this time he discovered the dynamic instability of microtubules. Later he worked at the National Institute for Medical Research in London. In 1987 he returned to San Francisco to become an Assistant Professor at UCSF. In 1997 he moved to the Cell Biology Department at Harvard Medical School where he co-founded the Institute for Chemistry and Cell Biology.

Dr. Mitchison was a founding member of the HMS Department of Systems Biology, which started in 2004. He is currently Deputy Chair of the department, and Co-director of the Systems Biology PhD Program. He was elected a Fellow of the Royal Society in 1997, and member of the American Association of Arts and Sciences in 2008. In 2010 he served as President of the American Society of Cell Biology. And most recently in 2014 he became a member of the National Academy of Sciences.

Remaining mysteries of the cytoplasm.
Authors: Authors: Mitchison TJ.
Mol Biol Cell
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Spindle assembly in the absence of a RanGTP gradient requires localized CPC activity.
Authors: Authors: Maresca TJ, Groen AC, Gatlin JC, Ohi R, Mitchison TJ, Salmon ED.
Curr Biol
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Cell polarization during monopolar cytokinesis.
Authors: Authors: Hu CK, Coughlin M, Field CM, Mitchison TJ.
J Cell Biol
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Structural insights into yeast septin organization from polarized fluorescence microscopy.
Authors: Authors: Vrabioiu AM, Mitchison TJ.
Nature
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Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor.
Authors: Authors: Yarrow JC, Totsukawa G, Charras GT, Mitchison TJ.
Chem Biol
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Targeting cell division: small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality.
Authors: Authors: Margalit DN, Romberg L, Mets RB, Hebert AM, Mitchison TJ, Kirschner MW, RayChaudhuri D.
Proc Natl Acad Sci U S A
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Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration.
Authors: Authors: Zhai Q, Wang J, Kim A, Liu Q, Watts R, Hoopfer E, Mitchison T, Luo L, He Z.
Neuron
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Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5.
Authors: Authors: Maliga Z, Kapoor TM, Mitchison TJ.
Chem Biol
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Dynamic confocal imaging of mitochondria in swimming Tetrahymena and of microtubule poleward flux in Xenopus extract spindles.
Authors: Authors: Maddox P, Desai A, Salmon ED, Mitchison TJ, Oogema K, Kapoor T, Matsumoto B, Inoué S.
Biol Bull
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Caged fluorescent probes.
Authors: Authors: Mitchison TJ, Sawin KE, Theriot JA, Gee K, Mallavarapu A.
Methods Enzymol
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