Tim Mitchison

Timothy Mitchison, PhD

Hasib Sabbagh Professor of Systems Biology, Harvard Medical School

Tim Mitchison, PhD, received his BA in Biochemistry from Oxford University, England, in 1980, and his PhD from the University of California, San Francisco (UCSF), in Biochemistry and Biophysics in 1984, where he worked with Professor Marc Kirschner. At this time he discovered the dynamic instability of microtubules. Later he worked at the National Institute for Medical Research in London. In 1987 he returned to San Francisco to become an Assistant Professor at UCSF. In 1997 he moved to the Cell Biology Department at Harvard Medical School where he co-founded the Institute for Chemistry and Cell Biology.

Dr. Mitchison was a founding member of the HMS Department of Systems Biology, which started in 2004. He is currently Deputy Chair of the department, and Co-director of the Systems Biology PhD Program. He was elected a Fellow of the Royal Society in 1997, and member of the American Association of Arts and Sciences in 2008. In 2010 he served as President of the American Society of Cell Biology. And most recently in 2014 he became a member of the National Academy of Sciences.

Graduate education. Interdisciplinary graduate training in teaching labs.
Authors: Authors: Vale RD, DeRisi J, Phillips R, Mullins RD, Waterman C, Mitchison TJ.
Science
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Rapid induction of apoptosis during Kinesin-5 inhibitor-induced mitotic arrest in HL60 cells.
Authors: Authors: Tang Y, Orth JD, Xie T, Mitchison TJ.
Cancer Lett
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Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly.
Authors: Authors: Huang HC, Shi J, Orth JD, Mitchison TJ.
Cancer Cell
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Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate.
Authors: Authors: Orth JD, Tang Y, Shi J, Loy CT, Amendt C, Wilm C, Zenke FT, Mitchison TJ.
Mol Cancer Ther
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Slide-and-cluster models for spindle assembly.
Authors: Authors: Burbank KS, Mitchison TJ, Fisher DS.
Curr Biol
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Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function.
Authors: Authors: Chang P, Coughlin M, Mitchison TJ.
Nat Cell Biol
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XRHAMM functions in ran-dependent microtubule nucleation and pole formation during anastral spindle assembly.
Authors: Authors: Groen AC, Cameron LA, Coughlin M, Miyamoto DT, Mitchison TJ, Ohi R.
Curr Biol
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Microtubule plus-end dynamics in Xenopus egg extract spindles.
Authors: Authors: Tirnauer JS, Salmon ED, Mitchison TJ.
Mol Biol Cell
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Mammalian septins nomenclature.
Authors: Authors: Macara IG, Baldarelli R, Field CM, Glotzer M, Hayashi Y, Hsu SC, Kennedy MB, Kinoshita M, Longtine M, Low C, Maltais LJ, McKenzie L, Mitchison TJ, Nishikawa T, Noda M, Petty EM, Peifer M, Pringle JR, Robinson PJ, Roth D, Russell SE, Stuhlmann H, Tanaka M, Tanaka T, Trimble WS, Ware J, Zeleznik-Le NJ, Zieger B.
Mol Biol Cell
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Mitosis: a history of division.
Authors: Authors: Mitchison TJ, Salmon ED.
Nat Cell Biol
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