Tim Mitchison

Timothy Mitchison, PhD

Hasib Sabbagh Professor of Systems Biology, Harvard Medical School

Tim Mitchison, PhD, received his BA in Biochemistry from Oxford University, England, in 1980, and his PhD from the University of California, San Francisco (UCSF), in Biochemistry and Biophysics in 1984, where he worked with Professor Marc Kirschner. At this time he discovered the dynamic instability of microtubules. Later he worked at the National Institute for Medical Research in London. In 1987 he returned to San Francisco to become an Assistant Professor at UCSF. In 1997 he moved to the Cell Biology Department at Harvard Medical School where he co-founded the Institute for Chemistry and Cell Biology.

Dr. Mitchison was a founding member of the HMS Department of Systems Biology, which started in 2004. He is currently Deputy Chair of the department, and Co-director of the Systems Biology PhD Program. He was elected a Fellow of the Royal Society in 1997, and member of the American Association of Arts and Sciences in 2008. In 2010 he served as President of the American Society of Cell Biology. And most recently in 2014 he became a member of the National Academy of Sciences.

Poleward kinetochore fiber movement occurs during both metaphase and anaphase-A in newt lung cell mitosis.
Authors: Authors: Mitchison TJ, Salmon ED.
J Cell Biol
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Two different microtubule-based motor activities with opposite polarities in kinetochores.
Authors: Authors: Hyman AA, Mitchison TJ.
Nature
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Polewards chromosome movement driven by microtubule depolymerization in vitro.
Authors: Authors: Koshland DE, Mitchison TJ, Kirschner MW.
Nature
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Dynamic instability of microtubule growth.
Authors: Authors: Mitchison T, Kirschner M.
Nature
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A PDGFRa-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine.
Authors: Authors: Jun HJ, Appleman VA, Wu HJ, Rose CM, Pineda JJ, Yeo AT, Delcuze B, Lee C, Gyuris A, Zhu H, Woolfenden S, Bronisz A, Nakano I, Chiocca EA, Bronson RT, Ligon KL, Sarkaria JN, Gygi SP, Michor F, Mitchison TJ, Charest A.
Nat Commun
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27 T ultra-high static magnetic field changes orientation and morphology of mitotic spindles in human cells.
Authors: Authors: Zhang L, Hou Y, Li Z, Ji X, Wang Z, Wang H, Tian X, Yu F, Yang Z, Pi L, Mitchison TJ, Lu Q, Zhang X.
Elife
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In vivo cell-cycle profiling in xenograft tumors by quantitative intravital microscopy.
Authors: Authors: Chittajallu DR, Florian S, Kohler RH, Iwamoto Y, Orth JD, Weissleder R, Danuser G, Mitchison TJ.
Nat Methods
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Xenopus egg cytoplasm with intact actin.
Authors: Authors: Field CM, Nguyen PA, Ishihara K, Groen AC, Mitchison TJ.
Methods Enzymol
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