Tim Mitchison

Timothy Mitchison, PhD

Hasib Sabbagh Professor of Systems Biology, Harvard Medical School

Tim Mitchison, PhD, received his BA in Biochemistry from Oxford University, England, in 1980, and his PhD from the University of California, San Francisco (UCSF), in Biochemistry and Biophysics in 1984, where he worked with Professor Marc Kirschner. At this time he discovered the dynamic instability of microtubules. Later he worked at the National Institute for Medical Research in London. In 1987 he returned to San Francisco to become an Assistant Professor at UCSF. In 1997 he moved to the Cell Biology Department at Harvard Medical School where he co-founded the Institute for Chemistry and Cell Biology.

Dr. Mitchison was a founding member of the HMS Department of Systems Biology, which started in 2004. He is currently Deputy Chair of the department, and Co-director of the Systems Biology PhD Program. He was elected a Fellow of the Royal Society in 1997, and member of the American Association of Arts and Sciences in 2008. In 2010 he served as President of the American Society of Cell Biology. And most recently in 2014 he became a member of the National Academy of Sciences.

Functional overlap of microtubule assembly factors in chromatin-promoted spindle assembly.
Authors: Authors: Groen AC, Maresca TJ, Gatlin JC, Salmon ED, Mitchison TJ.
Mol Biol Cell
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Coronin-1A stabilizes F-actin by bridging adjacent actin protomers and stapling opposite strands of the actin filament.
Authors: Authors: Galkin VE, Orlova A, Brieher W, Kueh HY, Mitchison TJ, Egelman EH.
J Mol Biol
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Noble metals strip peptides from class II MHC proteins.
Authors: Authors: De Wall SL, Painter C, Stone JD, Bandaranayake R, Wiley DC, Mitchison TJ, Stern LJ, DeDecker BS.
Nat Chem Biol
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Kinetic mechanism of blebbistatin inhibition of nonmuscle myosin IIb.
Authors: Authors: Ramamurthy B, Yengo CM, Straight AF, Mitchison TJ, Sweeney HL.
Biochemistry
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Fascin-mediated propulsion of Listeria monocytogenes independent of frequent nucleation by the Arp2/3 complex.
Authors: Authors: Brieher WM, Coughlin M, Mitchison TJ.
J Cell Biol
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Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor.
Authors: Authors: Straight AF, Cheung A, Limouze J, Chen I, Westwood NJ, Sellers JR, Mitchison TJ.
Science
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A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions.
Authors: Authors: Peterson JR, Lokey RS, Mitchison TJ, Kirschner MW.
Proc Natl Acad Sci U S A
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The bipolar kinesin, KLP61F, cross-links microtubules within interpolar microtubule bundles of Drosophila embryonic mitotic spindles.
Authors: Authors: Sharp DJ, McDonald KL, Brown HM, Matthies HJ, Walczak C, Vale RD, Mitchison TJ, Scholey JM.
J Cell Biol
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A method that allows the assembly of kinetochore components onto chromosomes condensed in clarified Xenopus egg extracts.
Authors: Authors: Desai A, Deacon HW, Walczak CE, Mitchison TJ.
Proc Natl Acad Sci U S A
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XKCM1: a Xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly.
Authors: Authors: Walczak CE, Mitchison TJ, Desai A.
Cell
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