Wade Harper, Ph.D.

Bert and Natalie Vallee Professor of Molecular Pathology, Harvard Medical School
617-432-6590
Deletion of the Cul1 gene in mice causes arrest in early embryogenesis and accumulation of cyclin E.
Authors: Authors: Wang Y, Penfold S, Tang X, Hattori N, Riley P, Harper JW, Cross JC, Tyers M.
Curr Biol
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Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control.
Authors: Authors: Deng C, Zhang P, Harper JW, Elledge SJ, Leder P.
Cell
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The anaphase-promoting complex: it's not just for mitosis any more.
Authors: Authors: Harper JW, Burton JL, Solomon MJ.
Genes Dev
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SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex.
Authors: Authors: Kitagawa K, Skowyra D, Elledge SJ, Harper JW, Hieter P.
Mol Cell
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p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.
Authors: Authors: Matsuoka S, Edwards MC, Bai C, Parker S, Zhang P, Baldini A, Harper JW, Elledge SJ.
Genes Dev
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Efp: a ring of independence?
Authors: Authors: Nalepa G, Harper JW.
Nat Med
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How the cyclin became a cyclin: regulated proteolysis in the cell cycle.
Authors: Authors: Koepp DM, Harper JW, Elledge SJ.
Cell
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p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells.
Authors: Authors: Parker SB, Eichele G, Zhang P, Rawls A, Sands AT, Bradley A, Olson EN, Harper JW, Elledge SJ.
Science
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RING finger specificity in SCF-driven protein destruction.
Authors: Authors: Jin J, Harper JW.
Dev Cell
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Skipping into the E2F1-destruction pathway.
Authors: Authors: Harper JW, Elledge SJ.
Nat Cell Biol
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