Wade Harper, Ph.D.

Bert and Natalie Vallee Professor of Molecular Pathology, Harvard Medical School
617-432-6590
Stuck in the middle: drugging the ubiquitin system at the e2 step.
Authors: Authors: Harper JW, King RW.
Cell
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Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase.
Authors: Authors: Koepp DM, Schaefer LK, Ye X, Keyomarsi K, Chu C, Harper JW, Elledge SJ.
Science
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Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development.
Authors: Authors: Zhang P, Wong C, DePinho RA, Harper JW, Elledge SJ.
Genes Dev
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The DNA damage response: ten years after.
Authors: Authors: Harper JW, Elledge SJ.
Mol Cell
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Protein destruction: adapting roles for Cks proteins.
Authors: Authors: Harper JW.
Curr Biol
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G1 cyclin-dependent kinases are sufficient to initiate DNA synthesis in quiescent human fibroblasts.
Authors: Authors: Connell-Crowley L, Elledge SJ, Harper JW.
Curr Biol
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Structural complexity in ubiquitin recognition.
Authors: Authors: Harper JW, Schulman BA.
Cell
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Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.
Authors: Authors: Schulman BA, Carrano AC, Jeffrey PD, Bowen Z, Kinnucan ER, Finnin MS, Elledge SJ, Harper JW, Pagano M, Pavletich NP.
Nature
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F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex.
Authors: Authors: Skowyra D, Craig KL, Tyers M, Elledge SJ, Harper JW.
Cell
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High levels of phosphorylated form of Akt-1 in prostate cancer and non-neoplastic prostate tissues are strong predictors of biochemical recurrence.
Authors: Authors: Ayala G, Thompson T, Yang G, Frolov A, Li R, Scardino P, Ohori M, Wheeler T, Harper W.
Clin Cancer Res
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