Wade Harper, Ph.D.

Bert and Natalie Vallee Professor of Molecular Pathology, Harvard Medical School
617-432-6590
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
Authors: Authors: Zheng N, Schulman BA, Song L, Miller JJ, Jeffrey PD, Wang P, Chu C, Koepp DM, Elledge SJ, Pagano M, Conaway RC, Conaway JW, Harper JW, Pavletich NP.
Nature
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Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase.
Authors: Authors: Kamura T, Koepp DM, Conrad MN, Skowyra D, Moreland RJ, Iliopoulos O, Lane WS, Kaelin WG, Elledge SJ, Conaway RC, Harper JW, Conaway JW.
Science
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Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4.
Authors: Authors: Leng X, Noble M, Adams PD, Qin J, Harper JW.
Mol Cell Biol
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Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.
Authors: Authors: Skowyra D, Koepp DM, Kamura T, Conrad MN, Conaway RC, Conaway JW, Elledge SJ, Harper JW.
Science
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A phosphorylation-driven ubiquitination switch for cell-cycle control.
Authors: Authors: Harper JW.
Trends Cell Biol
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The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro.
Authors: Authors: Winston JT, Strack P, Beer-Romero P, Chu CY, Elledge SJ, Harper JW.
Genes Dev
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The seven wonders of ubiquitin: a multi-interview: Personal insights into the ubiquitin field. Interview by Nonia Pariente.
Authors: Authors: Dikic I, Harper W, Hay R, Langer T, Rape M, Sixma T, Walczak H.
EMBO Rep
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Implications for the ubiquitination reaction of the anaphase-promoting complex from the crystal structure of the Doc1/Apc10 subunit.
Authors: Authors: Au SW, Leng X, Harper JW, Barford D.
J Mol Biol
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Interaction between cyclin-dependent kinases and human papillomavirus replication-initiation protein E1 is required for efficient viral replication.
Authors: Authors: Ma T, Zou N, Lin BY, Chow LT, Harper JW.
Proc Natl Acad Sci U S A
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Understanding cullin-RING E3 biology through proteomics-based substrate identification.
Authors: Authors: Harper JW, Tan MK.
Mol Cell Proteomics
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