Zuzana Tothova, MD, PhD

Assistant Professor of Medicine, Dana-Farber Cancer Institute
Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML.
Authors: Authors: Puram RV, Kowalczyk MS, de Boer CG, Schneider RK, Miller PG, McConkey M, Tothova Z, Tejero H, Heckl D, Järås M, Chen MC, Li H, Tamayo A, Cowley GS, Rozenblatt-Rosen O, Al-Shahrour F, Regev A, Ebert BL.
Cell
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FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis.
Authors: Authors: Paik JH, Kollipara R, Chu G, Ji H, Xiao Y, Ding Z, Miao L, Tothova Z, Horner JW, Carrasco DR, Jiang S, Gilliland DG, Chin L, Wong WH, Castrillon DH, DePinho RA.
Cell
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Mutant Calreticulin Requires Both Its Mutant C-terminus and the Thrombopoietin Receptor for Oncogenic Transformation.
Authors: Authors: Elf S, Abdelfattah NS, Chen E, Perales-Patón J, Rosen EA, Ko A, Peisker F, Florescu N, Giannini S, Wolach O, Morgan EA, Tothova Z, Losman JA, Schneider RK, Al-Shahrour F, Mullally A.
Cancer Discov
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FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress.
Authors: Authors: Tothova Z, Kollipara R, Huntly BJ, Lee BH, Castrillon DH, Cullen DE, McDowell EP, Lazo-Kallanian S, Williams IR, Sears C, Armstrong SA, Passegué E, DePinho RA, Gilliland DG.
Cell
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Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9.
Authors: Authors: Doench JG, Fusi N, Sullender M, Hegde M, Vaimberg EW, Donovan KF, Smith I, Tothova Z, Wilen C, Orchard R, Virgin HW, Listgarten J, Root DE.
Nat Biotechnol
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The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.
Authors: Authors: Masutomi K, Possemato R, Wong JM, Currier JL, Tothova Z, Manola JB, Ganesan S, Lansdorp PM, Collins K, Hahn WC.
Proc Natl Acad Sci U S A
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Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation.
Authors: Authors: Doench JG, Hartenian E, Graham DB, Tothova Z, Hegde M, Smith I, Sullender M, Ebert BL, Xavier RJ, Root DE.
Nat Biotechnol
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NPM-ALK fusion kinase of anaplastic large-cell lymphoma regulates survival and proliferative signaling through modulation of FOXO3a.
Authors: Authors: Gu TL, Tothova Z, Scheijen B, Griffin JD, Gilliland DG, Sternberg DW.
Blood
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Hemophagocytic Syndrome and Critical Illness: New Insights into Diagnosis and Management.
Authors: Authors: Tothova Z, Berliner N.
J Intensive Care Med
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Niche-based screening identifies small-molecule inhibitors of leukemia stem cells.
Authors: Authors: Hartwell KA, Miller PG, Mukherjee S, Kahn AR, Stewart AL, Logan DJ, Negri JM, Duvet M, Järås M, Puram R, Dancik V, Al-Shahrour F, Kindler T, Tothova Z, Chattopadhyay S, Hasaka T, Narayan R, Dai M, Huang C, Shterental S, Chu LP, Haydu JE, Shieh JH, Steensma DP, Munoz B, Bittker JA, Shamji AF, Clemons PA, Tolliday NJ, Carpenter AE, Gilliland DG, Stern AM, Moore MAS, Scadden DT, Schreiber SL, Ebert BL, Golub TR.
Nat Chem Biol
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