Zuzana Tothova, MD, PhD

Assistant Professor of Medicine, Dana-Farber Cancer Institute
AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias.
Authors: Authors: Sykes SM, Lane SW, Bullinger L, Kalaitzidis D, Yusuf R, Saez B, Ferraro F, Mercier F, Singh H, Brumme KM, Acharya SS, Scholl C, Schöll C, Tothova Z, Attar EC, Fröhling S, DePinho RA, Armstrong SA, Gilliland DG, Scadden DT.
Cell
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Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification.
Authors: Authors: Cornejo MG, Mabialah V, Sykes SM, Khandan T, Lo Celso C, Lopez CK, Rivera-Muñoz P, Rameau P, Tothova Z, Aster JC, DePinho RA, Scadden DT, Gilliland DG, Mercher T.
Blood
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mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion.
Authors: Authors: Lee JY, Nakada D, Yilmaz OH, Tothova Z, Joseph NM, Lim MS, Gilliland DG, Morrison SJ.
Cell Stem Cell
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A radical bailout strategy for cancer stem cells.
Authors: Authors: Tothova Z, Gilliland DG.
Cell Stem Cell
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FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia.
Authors: Authors: Lee BH, Tothova Z, Levine RL, Anderson K, Buza-Vidas N, Cullen DE, McDowell EP, Adelsperger J, Fröhling S, Huntly BJ, Beran M, Jacobsen SE, Gilliland DG.
Cancer Cell
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Intergenerational epigenetic inheritance of cancer susceptibility in mammals.
Authors: Authors: Lesch BJ, Tothova Z, Morgan EA, Liao Z, Bronson RT, Ebert BL, Page DC.
Elife
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FoxO transcription factors and stem cell homeostasis: insights from the hematopoietic system.
Authors: Authors: Tothova Z, Gilliland DG.
Cell Stem Cell
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Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia.
Authors: Authors: Tothova Z, Krill-Burger JM, Popova KD, Landers CC, Sievers QL, Yudovich D, Belizaire R, Aster JC, Morgan EA, Tsherniak A, Ebert BL.
Cell Stem Cell
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[FoxO: stress or eternal life].
Authors: Authors: Tothova Z, Mercher T.
Med Sci (Paris)
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Doubling Down on Mutant RAS Can MEK or Break Leukemia.
Authors: Authors: Tothova Z, Ebert BL.
Cell
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