Zuzana Tothova, MD, PhD

Assistant Professor of Medicine, Dana-Farber Cancer Institute
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9.
Authors: Authors: Doench JG, Fusi N, Sullender M, Hegde M, Vaimberg EW, Donovan KF, Smith I, Tothova Z, Wilen C, Orchard R, Virgin HW, Listgarten J, Root DE.
Nat Biotechnol
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The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.
Authors: Authors: Masutomi K, Possemato R, Wong JM, Currier JL, Tothova Z, Manola JB, Ganesan S, Lansdorp PM, Collins K, Hahn WC.
Proc Natl Acad Sci U S A
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Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation.
Authors: Authors: Doench JG, Hartenian E, Graham DB, Tothova Z, Hegde M, Smith I, Sullender M, Ebert BL, Xavier RJ, Root DE.
Nat Biotechnol
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NPM-ALK fusion kinase of anaplastic large-cell lymphoma regulates survival and proliferative signaling through modulation of FOXO3a.
Authors: Authors: Gu TL, Tothova Z, Scheijen B, Griffin JD, Gilliland DG, Sternberg DW.
Blood
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Hemophagocytic Syndrome and Critical Illness: New Insights into Diagnosis and Management.
Authors: Authors: Tothova Z, Berliner N.
J Intensive Care Med
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Niche-based screening identifies small-molecule inhibitors of leukemia stem cells.
Authors: Authors: Hartwell KA, Miller PG, Mukherjee S, Kahn AR, Stewart AL, Logan DJ, Negri JM, Duvet M, Järås M, Puram R, Dancik V, Al-Shahrour F, Kindler T, Tothova Z, Chattopadhyay S, Hasaka T, Narayan R, Dai M, Huang C, Shterental S, Chu LP, Haydu JE, Shieh JH, Steensma DP, Munoz B, Bittker JA, Shamji AF, Clemons PA, Tolliday NJ, Carpenter AE, Gilliland DG, Stern AM, Moore MAS, Scadden DT, Schreiber SL, Ebert BL, Golub TR.
Nat Chem Biol
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New strategies in myelodysplastic syndromes: application of molecular diagnostics to clinical practice.
Authors: Authors: Tothova Z, Steensma DP, Ebert BL.
Clin Cancer Res
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Anaplastic lymphoma kinase-directed therapy in inflammatory myofibroblastic tumors.
Authors: Authors: Tothova Z, Wagner AJ.
Curr Opin Oncol
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AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias.
Authors: Authors: Sykes SM, Lane SW, Bullinger L, Kalaitzidis D, Yusuf R, Saez B, Ferraro F, Mercier F, Singh H, Brumme KM, Acharya SS, Scholl C, Schöll C, Tothova Z, Attar EC, Fröhling S, DePinho RA, Armstrong SA, Gilliland DG, Scadden DT.
Cell
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Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification.
Authors: Authors: Cornejo MG, Mabialah V, Sykes SM, Khandan T, Lo Celso C, Lopez CK, Rivera-Muñoz P, Rameau P, Tothova Z, Aster JC, DePinho RA, Scadden DT, Gilliland DG, Mercher T.
Blood
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