Amy Wagers

Amy Wagers, PhD

Forst Family Professor of Stem Cell and Regenerative Biology, Faculty of Arts & Sciences, Harvard University

Dr. Amy Wagers is a Harvard College Professor and the Forst Family Professor and Co-Chair of the Department of Stem Cell and Regenerative Biology at Harvard University. She is also a Principal Faculty member of the Harvard Stem Cell Institute, a Senior Investigator in the Section on Islet Cell and Regenerative Biology at the Joslin Diabetes Center and a member of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School.  Dr. Wagers’ laboratory investigates how changes in stem cell activity impact tissue homeostasis and repair throughout life, and how stem cells may be harnessed for regenerative medicine using cell transplantation and gene editing approaches.

Hematopoietic cells maintain hematopoietic fates upon entering the brain.
Authors: Authors: Massengale M, Wagers AJ, Vogel H, Weissman IL.
J Exp Med
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Langerhans cells renew in the skin throughout life under steady-state conditions.
Authors: Authors: Merad M, Manz MG, Karsunky H, Wagers A, Peters W, Charo I, Weissman IL, Cyster JG, Engleman EG.
Nat Immunol
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IL-12 and IL-4 control T cell adhesion to endothelial selectins through opposite effects on FucT-VII gene expression
Authors: Authors: Wagers AJ, Waters CM, Stoolman LM, Kansas GS
Journal of Experimental Medicine
Structural basis for potency differences between GDF8 and GDF11.
Authors: Authors: Walker RG, Czepnik M, Goebel EJ, McCoy JC, Vujic A, Cho M, Oh J, Aykul S, Walton KL, Schang G, Bernard DJ, Hinck AP, Harrison CA, Martinez-Hackert E, Wagers AJ, Lee RT, Thompson TB.
BMC Biol
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In vivo gene editing in dystrophic mouse muscle and muscle stem cells.
Authors: Authors: Tabebordbar M, Zhu K, Cheng JKW, Chew WL, Widrick JJ, Yan WX, Maesner C, Wu EY, Xiao R, Ran FA, Cong L, Zhang F, Vandenberghe LH, Church GM, Wagers AJ.
Science
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Rhabdomyosarcoma: current challenges and their implications for developing therapies.
Authors: Authors: Hettmer S, Li Z, Billin AN, Barr FG, Cornelison DD, Ehrlich AR, Guttridge DC, Hayes-Jordan A, Helman LJ, Houghton PJ, Khan J, Langenau DM, Linardic CM, Pal R, Partridge TA, Pavlath GK, Rota R, Schäfer BW, Shipley J, Stillman B, Wexler LH, Wagers AJ, Keller C.
Cold Spring Harb Perspect Med
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Anaplastic rhabdomyosarcoma in TP53 germline mutation carriers.
Authors: Authors: Hettmer S, Archer NM, Somers GR, Novokmet A, Wagers AJ, Diller L, Rodriguez-Galindo C, Teot LA, Malkin D.
Cancer
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Liver-derived systemic factors drive ß cell hyperplasia in insulin-resistant states.
Authors: Authors: El Ouaamari A, Kawamori D, Dirice E, Liew CW, Shadrach JL, Hu J, Katsuta H, Hollister-Lock J, Qian WJ, Wagers AJ, Kulkarni RN.
Cell Rep
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Use of cellular context to determine sarcoma phenotype in a new mouse sarcoma model.
Authors: Authors: Hettmer S, Liu J, Miller CM, Bronson RT, Langenau DM, Wagers AJ.
J Clin Oncol
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Id3 is a direct transcriptional target of Pax7 in quiescent satellite cells.
Authors: Authors: Kumar D, Shadrach JL, Wagers AJ, Lassar AB.
Mol Biol Cell
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