Bruce Bean, PhD
Robert Winthrop Professor of Neurobiology, Harvard Medical School
Bruce Bean is Robert Winthrop Professor of Neurobiology at Harvard Medical School. Bean graduated from Harvard College, received a Ph.D. in Biophysics from the University of Rochester, did postdoctoral work with Richard W. Tsien at the Yale School of Medicine, and has previously held faculty positions at the University of Iowa and the Vollum Institute of Oregon Health Sciences University. His research interests are in the electrophysiology of neurons and muscle and in using ion channels to develop new therapeutic treatments.
Subthreshold sodium currents and pacemaking of subthalamic neurons: modulation by slow inactivation.
Voltage-dependent inhibition of N- and P-type calcium channels by the peptide toxin omega-grammotoxin-SIA.
Authors: Authors: McDonough SI, Lampe RA, Keith RA, Bean BP.
Mol Pharmacol
View full abstract on Pubmed
Mol Pharmacol
View full abstract on Pubmed
Modulation of N-type calcium channels in bullfrog sympathetic neurons by luteinizing hormone-releasing hormone: kinetics and voltage dependence.
Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence.
Tetrodotoxin block of sodium channels in rabbit Purkinje fibers. Interactions between toxin binding and channel gating.
Authors: Authors: Cohen CJ, Bean BP, Colatsky TJ, Tsien RW.
J Gen Physiol
View full abstract on Pubmed
J Gen Physiol
View full abstract on Pubmed
Action Potential Broadening in Capsaicin-Sensitive DRG Neurons from Frequency-Dependent Reduction of Kv3 Current.
Phenotyping the function of TRPV1-expressing sensory neurons by targeted axonal silencing.
Authors: Authors: Brenneis C, Kistner K, Puopolo M, Segal D, Roberson D, Sisignano M, Labocha S, Ferreirós N, Strominger A, Cobos EJ, Ghasemlou N, Geisslinger G, Reeh PW, Bean BP, Woolf CJ.
J Neurosci
View full abstract on Pubmed
J Neurosci
View full abstract on Pubmed
Dynamic, nonlinear feedback regulation of slow pacemaking by A-type potassium current in ventral tegmental area neurons.
Properties and functional role of voltage-dependent potassium channels in dendrites of rat cerebellar Purkinje neurons.
Altered subthreshold sodium currents and disrupted firing patterns in Purkinje neurons of Scn8a mutant mice.