Clifford Woolf, PhD, MB, BCh
Professor of Neurology, Boston Children's Hospital
p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia.
Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity.
Authors: Authors: Samad TA, Moore KA, Sapirstein A, Billet S, Allchorne A, Poole S, Bonventre JV, Woolf CJ.
Nature
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Nature
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Diversity of expression of the sensory neuron-specific TTX-resistant voltage-gated sodium ion channels SNS and SNS2.
Authors: Authors: Amaya F, Decosterd I, Samad TA, Plumpton C, Tate S, Mannion RJ, Costigan M, Woolf CJ.
Mol Cell Neurosci
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Mol Cell Neurosci
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Peripheral inflammation increases the capsaicin sensitivity of dorsal root ganglion neurons in a nerve growth factor-dependent manner.
Authors: Authors: Nicholas RS, Winter J, Wren P, Bergmann R, Woolf CJ.
Neuroscience
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Neuroscience
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The progressive tactile hyperalgesia induced by peripheral inflammation is nerve growth factor dependent.
Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma.
Authors: Authors: Chen H, Cho KS, Vu THK, Shen CH, Kaur M, Chen G, Mathew R, McHam ML, Fazelat A, Lashkari K, Au NPB, Tse JKY, Li Y, Yu H, Yang L, Stein-Streilein J, Ma CHE, Woolf CJ, Whary MT, Jager MJ, Fox JG, Chen J, Chen DF.
Nat Commun
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Nat Commun
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Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain.
Authors: Authors: Sisignano M, Angioni C, Park CK, Meyer Dos Santos S, Jordan H, Kuzikov M, Liu D, Zinn S, Hohman SW, Schreiber Y, Zimmer B, Schmidt M, Lu R, Suo J, Zhang DD, Schäfer SM, Hofmann M, Yekkirala AS, de Bruin N, Parnham MJ, Woolf CJ, Ji RR, Scholich K, Geisslinger G.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation.
Authors: Authors: Talbot S, Abdulnour RE, Burkett PR, Lee S, Cronin SJ, Pascal MA, Laedermann C, Foster SL, Tran JV, Lai N, Chiu IM, Ghasemlou N, DiBiase M, Roberson D, Von Hehn C, Agac B, Haworth O, Seki H, Penninger JM, Kuchroo VK, Bean BP, Levy BD, Woolf CJ.
Neuron
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Neuron
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Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons.
Authors: Authors: Wainger BJ, Kiskinis E, Mellin C, Wiskow O, Han SS, Sandoe J, Perez NP, Williams LA, Lee S, Boulting G, Berry JD, Brown RH, Cudkowicz ME, Bean BP, Eggan K, Woolf CJ.
Cell Rep
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Cell Rep
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Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology.