David Golan

David Golan, MD, PhD

Dean for Research Operations and Global Programs, Harvard Medical School
George R. Minot Professor of Medicine, Harvard Medical School
Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School

David E. Golan, the George R. Minot Professor of Medicine and Professor of Biological Chemistry and Molecular Pharmacology at HMS, was appointed dean for research operations and global programs in 2019. He previously served for 11 years as HMS dean for basic science and graduate education and special advisor for global programs. His laboratory in the Department of Biological Chemistry and Molecular Pharmacology applies biophysical and cell-imaging methods to the study of membrane proteins in blood cells. Dr. Golan is a senior physician in the Department of Medicine at Brigham and Women’s Hospital and Dana-Farber Cancer Institute, where he sees patients as a practicing hematologist and clinician teacher. Dr. Golan founded and directed the core course in pharmacology in the New Pathway curriculum at HMS from 1989 to 2006, and he co-directs a translational pharmacology course that brings together PhD students in the Therapeutics Graduate Program with MD fellows in the Master of Medical Sciences Program in Clinical Investigation at HMS. He also co-directs the Harvard Therapeutics Graduate Program and is editor-in-chief of Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, an award-winning textbook of pharmacology that is used worldwide. In his role as dean for research operations and global programs, Dr. Golan is responsible for planning, coordination and operations involving research in the School’s basic and social science departments and for planning, implementation and oversight of interdisciplinary, interdepartmental, School-wide, inter-institutional and global research initiatives and technology platforms at HMS.

Involvement of IGF-1R regulation by miR-515-5p modifies breast cancer risk among BRCA1 carriers.
Authors: Authors: Gilam A, Edry L, Mamluk-Morag E, Bar-Ilan D, Avivi C, Golan D, Laitman Y, Barshack I, Friedman E, Shomron N.
Breast Cancer Res Treat
View full abstract on Pubmed
Biased hosting of intronic microRNA genes.
Authors: Authors: Golan D, Levy C, Friedman B, Shomron N.
Bioinformatics
View full abstract on Pubmed
Mechanisms of Cellular Avidity Regulation in CD2-CD58-Mediated T Cell Adhesion.
Authors: Authors: Zhu DM, Dustin ML, Cairo CW, Thatte HS, Golan DE.
ACS Chem Biol
View full abstract on Pubmed
CFTR is a pattern recognition molecule that extracts Pseudomonas aeruginosa LPS from the outer membrane into epithelial cells and activates NF-kappa B translocation.
Authors: Authors: Schroeder TH, Lee MM, Yacono PW, Cannon CL, Gerçeker AA, Golan DE, Pier GB.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Inactivation of retinoblastoma protein does not overcome the requirement for human cytomegalovirus UL97 in lamina disruption and nuclear egress.
Authors: Authors: Reim NI, Kamil JP, Wang D, Lin A, Sharma M, Ericsson M, Pesola JM, Golan DE, Coen DM.
J Virol
View full abstract on Pubmed
Dynamic regulation of CD45 lateral mobility by the spectrin-ankyrin cytoskeleton of T cells.
Authors: Authors: Cairo CW, Das R, Albohy A, Baca QJ, Pradhan D, Morrow JS, Coombs D, Golan DE.
J Biol Chem
View full abstract on Pubmed
Analysis of two-dimensional dissociation constant of laterally mobile cell adhesion molecules.
Authors: Authors: Zhu DM, Dustin ML, Cairo CW, Golan DE.
Biophys J
View full abstract on Pubmed
Control of calcium entry in human fibroblasts by frequency-dependent electrical stimulation.
Authors: Authors: Cho MR, Marler JP, Thatte HS, Golan DE.
Front Biosci
View full abstract on Pubmed
Identifying personal genomes by surname inference.
Authors: Authors: Gymrek M, McGuire AL, Golan D, Halperin E, Erlich Y.
Science
View full abstract on Pubmed
An evolutionary perspective of animal microRNAs and their targets.
Authors: Authors: Shomron N, Golan D, Hornstein E.
J Biomed Biotechnol
View full abstract on Pubmed