David Golan

David Golan, MD, PhD

Dean for Research Operations and Global Programs, Harvard Medical School
George R. Minot Professor of Medicine, Harvard Medical School
Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School

David E. Golan, the George R. Minot Professor of Medicine and Professor of Biological Chemistry and Molecular Pharmacology at HMS, was appointed dean for research operations and global programs in 2019. He previously served for 11 years as HMS dean for basic science and graduate education and special advisor for global programs. His laboratory in the Department of Biological Chemistry and Molecular Pharmacology applies biophysical and cell-imaging methods to the study of membrane proteins in blood cells. Dr. Golan is a senior physician in the Department of Medicine at Brigham and Women’s Hospital and Dana-Farber Cancer Institute, where he sees patients as a practicing hematologist and clinician teacher. Dr. Golan founded and directed the core course in pharmacology in the New Pathway curriculum at HMS from 1989 to 2006, and he co-directs a translational pharmacology course that brings together PhD students in the Therapeutics Graduate Program with MD fellows in the Master of Medical Sciences Program in Clinical Investigation at HMS. He also co-directs the Harvard Therapeutics Graduate Program and is editor-in-chief of Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, an award-winning textbook of pharmacology that is used worldwide. In his role as dean for research operations and global programs, Dr. Golan is responsible for planning, coordination and operations involving research in the School’s basic and social science departments and for planning, implementation and oversight of interdisciplinary, interdepartmental, School-wide, inter-institutional and global research initiatives and technology platforms at HMS.

Membrane protein dynamics and functional implications in mammalian cells.
Authors: Authors: Alenghat FJ, Golan DE.
Curr Top Membr
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C3b deposition on human erythrocytes induces the formation of a membrane skeleton-linked protein complex.
Authors: Authors: Karnchanaphanurach P, Mirchev R, Ghiran I, Asara JM, Papahadjopoulos-Sternberg B, Nicholson-Weller A, Golan DE.
J Clin Invest
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Site-specific protein labeling by Sfp phosphopantetheinyl transferase.
Authors: Authors: Yin J, Lin AJ, Golan DE, Walsh CT.
Nat Protoc
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Breast-fed and formula-fed infants do not differ in immunocompetent cell cytokine production despite differences in cell membrane fatty acid composition.
Authors: Authors: Granot E, Golan D, Berry EM.
Am J Clin Nutr
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Macrophages require Skap2 and Sirpa for integrin-stimulated cytoskeletal rearrangement.
Authors: Authors: Alenghat FJ, Baca QJ, Rubin NT, Pao LI, Matozaki T, Lowell CA, Golan DE, Neel BG, Swanson KD.
J Cell Sci
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Viral mimicry of Cdc2/cyclin-dependent kinase 1 mediates disruption of nuclear lamina during human cytomegalovirus nuclear egress.
Authors: Authors: Hamirally S, Kamil JP, Ndassa-Colday YM, Lin AJ, Jahng WJ, Baek MC, Noton S, Silva LA, Simpson-Holley M, Knipe DM, Golan DE, Marto JA, Coen DM.
PLoS Pathog
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Genetically encoded short peptide tag for versatile protein labeling by Sfp phosphopantetheinyl transferase.
Authors: Authors: Yin J, Straight PD, McLoughlin SM, Zhou Z, Lin AJ, Golan DE, Kelleher NL, Kolter R, Walsh CT.
Proc Natl Acad Sci U S A
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Integrin-dependent human macrophage migration induced by oscillatory electrical stimulation.
Authors: Authors: Cho MR, Thatte HS, Lee RC, Golan DE.
Ann Biomed Eng
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MARCKS protein mediates hydrogen peroxide regulation of endothelial permeability.
Authors: Authors: Jin BY, Lin AJ, Golan DE, Michel T.
Proc Natl Acad Sci U S A
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Hopping of a processivity factor on DNA revealed by single-molecule assays of diffusion.
Authors: Authors: Komazin-Meredith G, Mirchev R, Golan DE, van Oijen AM, Coen DM.
Proc Natl Acad Sci U S A
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