David Knipe, PhD

Higgins Professor of Microbiology and Molecular Genetics, Harvard Medical School
Generation of an Oncolytic Herpes Simplex Virus 1 Expressing Human MelanA.
Authors: Authors: Boscheinen JB, Thomann S, Knipe DM, DeLuca N, Schuler-Thurner B, Gross S, Dörrie J, Schaft N, Bach C, Rohrhofer A, Werner-Klein M, Schmidt B, Schuster P.
Front Immunol
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HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression.
Authors: Authors: Christensen MH, Jensen SB, Miettinen JJ, Luecke S, Prabakaran T, Reinert LS, Mettenleiter T, Chen ZJ, Knipe DM, Sandri-Goldin RM, Enquist LW, Hartmann R, Mogensen TH, Rice SA, Nyman TA, Matikainen S, Paludan SR.
EMBO J
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HSV-1 remodels host telomeres to facilitate viral replication.
Authors: Authors: Deng Z, Kim ET, Vladimirova O, Dheekollu J, Wang Z, Newhart A, Liu D, Myers JL, Hensley SE, Moffat J, Janicki SM, Fraser NW, Knipe DM, Weitzman MD, Lieberman PM.
Cell Rep
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Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein.
Authors: Authors: Orzalli MH, DeLuca NA, Knipe DM.
Proc Natl Acad Sci U S A
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Simian TRIM5alpha proteins reduce replication of herpes simplex virus.
Authors: Authors: Reszka N, Zhou C, Song B, Sodroski JG, Knipe DM.
Virology
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Disruption of the U(L)41 gene in the herpes simplex virus 2 dl5-29 mutant increases its immunogenicity and protective capacity in a murine model of genital herpes.
Authors: Authors: Dudek T, Mathews LC, Knipe DM.
Virology
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Genetic analysis of the SARS-coronavirus spike glycoprotein functional domains involved in cell-surface expression and cell-to-cell fusion.
Authors: Authors: Petit CM, Melancon JM, Chouljenko VN, Colgrove R, Farzan M, Knipe DM, Kousoulas KG.
Virology
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Effects of innate immunity on herpes simplex virus and its ability to kill tumor cells.
Authors: Authors: Wakimoto H, Johnson PR, Knipe DM, Chiocca EA.
Gene Ther
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Cutting edge: myeloid complement C3 enhances the humoral response to peripheral viral infection.
Authors: Authors: Verschoor A, Brockman MA, Knipe DM, Carroll MC.
J Immunol
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Influence of mucosal and parenteral immunization with a replication-defective mutant of HSV-2 on immune responses and protection from genital challenge.
Authors: Authors: Morrison LA, Da Costa XJ, Knipe DM.
Virology
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