David Knipe, PhD
Higgins Professor of Microbiology and Molecular Genetics, Harvard Medical School
Preexisting nuclear architecture defines the intranuclear location of herpesvirus DNA replication structures.
Correct intranuclear localization of herpes simplex virus DNA polymerase requires the viral ICP8 DNA-binding protein.
Authors: Authors: Bush M, Yager DR, Gao M, Weisshart K, Marcy AI, Coen DM, Knipe DM.
J Virol
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J Virol
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Mapping of the transcriptional initiation site of the herpes simplex virus type 1 ICP8 gene in infected and transfected cells.
Thermolabile in vivo DNA-binding activity associated with a protein encoded by mutants of herpes simplex virus type 1.
Localization of two cellular forms of the vesicular stomatitis viral glycoprotein.
Intramuscular delivery of replication-defective herpes simplex virus gives antigen expression in muscle syncytia and improved protection against pathogenic HSV-2 strains.
Authors: Authors: Diaz F, Gregory S, Nakashima H, Viapiano MS, Knipe DM.
Virology
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Virology
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Global Diversity within and between Human Herpesvirus 1 and 2 Glycoproteins.
Authors: Authors: Lamers SL, Newman RM, Laeyendecker O, Tobian AA, Colgrove RC, Ray SC, Koelle DM, Cohen J, Knipe DM, Quinn TC.
J Virol
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J Virol
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Genomic sequences of a low passage herpes simplex virus 2 clinical isolate and its plaque-purified derivative strain.
Authors: Authors: Colgrove R, Diaz F, Newman R, Saif S, Shea T, Young S, Henn M, Knipe DM.
Virology
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Virology
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Herpesviral replication compartments move and coalesce at nuclear speckles to enhance export of viral late mRNA.
Authors: Authors: Chang L, Godinez WJ, Kim IH, Tektonidis M, de Lanerolle P, Eils R, Rohr K, Knipe DM.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Herpes simplex virus ICP0 promotes both histone removal and acetylation on viral DNA during lytic infection.