David Knipe, PhD
Higgins Professor of Microbiology and Molecular Genetics, Harvard Medical School
Herpes simplex virus VP16, but not ICP0, is required to reduce histone occupancy and enhance histone acetylation on viral genomes in U2OS osteosarcoma cells.
Immunization with a replication-defective herpes simplex virus 2 mutant reduces herpes simplex virus 1 infection and prevents ocular disease.
The role of toll-like receptors in herpes simplex infection in neonates.
Authors: Authors: Kurt-Jones EA, Belko J, Yu C, Newburger PE, Wang J, Chan M, Knipe DM, Finberg RW.
J Infect Dis
View full abstract on Pubmed
J Infect Dis
View full abstract on Pubmed
C-terminal region of herpes simplex virus ICP8 protein needed for intranuclear localization.
Herpes simplex virus 1 ICP27 is required for transcription of two viral late (gamma 2) genes in infected cells.
Authors: Authors: Jean S, LeVan KM, Song B, Levine M, Knipe DM.
Virology
View full abstract on Pubmed
Virology
View full abstract on Pubmed
Accumulation of viral transcripts and DNA during establishment of latency by herpes simplex virus.
"Immunization against genital herpes disease: Factors in the design of a replication-impaired vaccine."
Authors: Authors: Knipe DM, Da Costa X, Morrison LA
In: Vaccines 1996
In: Vaccines 1996
The acidic amino-terminal region of herpes simplex virus type 1 alpha protein ICP27 is required for an essential lytic function.
Herpes simplex virus alpha protein ICP27 can inhibit or augment viral gene transactivation.
A genetic test for expression of a functional herpes simplex virus DNA-binding protein from a transfected plasmid.