David Knipe, PhD

Higgins Professor of Microbiology and Molecular Genetics, Harvard Medical School
CCCTC-Binding Factor Acts as a Heterochromatin Barrier on Herpes Simplex Viral Latent Chromatin and Contributes to Poised Latent Infection.
Authors: Authors: Lee JS, Raja P, Pan D, Pesola JM, Coen DM, Knipe DM.
MBio
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Clues to mechanisms of herpesviral latent infection and potential cures.
Authors: Authors: Knipe DM, Raja P, Lee JS.
Proc Natl Acad Sci U S A
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A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction.
Authors: Authors: Bonham KS, Orzalli MH, Hayashi K, Wolf AI, Glanemann C, Weninger W, Iwasaki A, Knipe DM, Kagan JC.
Cell
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Human cytomegalovirus UL44 concentrates at the periphery of replication compartments, the site of viral DNA synthesis.
Authors: Authors: Strang BL, Boulant S, Chang L, Knipe DM, Kirchhausen T, Coen DM.
J Virol
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Viral mimicry of Cdc2/cyclin-dependent kinase 1 mediates disruption of nuclear lamina during human cytomegalovirus nuclear egress.
Authors: Authors: Hamirally S, Kamil JP, Ndassa-Colday YM, Lin AJ, Jahng WJ, Baek MC, Noton S, Silva LA, Simpson-Holley M, Knipe DM, Golan DE, Marto JA, Coen DM.
PLoS Pathog
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Properties of a herpes simplex virus multiple immediate-early gene-deleted recombinant as a vaccine vector.
Authors: Authors: Watanabe D, Brockman MA, Ndung'u T, Mathews L, Lucas WT, Murphy CG, Felber BK, Pavlakis GN, Deluca NA, Knipe DM.
Virology
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Persistent expression of chemokine and chemokine receptor RNAs at primary and latent sites of herpes simplex virus 1 infection.
Authors: Authors: Cook WJ, Kramer MF, Walker RM, Burwell TJ, Holman HA, Coen DM, Knipe DM.
Virol J
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Type 3 reovirus neuroinvasion after intramuscular inoculation: direct invasion of nerve terminals and age-dependent pathogenesis.
Authors: Authors: Mann MA, Knipe DM, Fischbach GD, Fields BN.
Virology
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Persistent elevated expression of cytokine transcripts in ganglia latently infected with herpes simplex virus in the absence of ganglionic replication or reactivation.
Authors: Authors: Chen SH, Garber DA, Schaffer PA, Knipe DM, Coen DM.
Virology
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Assembly of herpes simplex virus replication proteins at two distinct intranuclear sites.
Authors: Authors: Uprichard SL, Knipe DM.
Virology
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