David Knipe, PhD
Higgins Professor of Microbiology and Molecular Genetics, Harvard Medical School
Herpes simplex virus 1 ICP27 is required for transcription of two viral late (gamma 2) genes in infected cells.
Authors: Authors: Jean S, LeVan KM, Song B, Levine M, Knipe DM.
Virology
View full abstract on Pubmed
Virology
View full abstract on Pubmed
Accumulation of viral transcripts and DNA during establishment of latency by herpes simplex virus.
"Immunization against genital herpes disease: Factors in the design of a replication-impaired vaccine."
Authors: Authors: Knipe DM, Da Costa X, Morrison LA
In: Vaccines 1996
In: Vaccines 1996
The acidic amino-terminal region of herpes simplex virus type 1 alpha protein ICP27 is required for an essential lytic function.
Herpes simplex virus alpha protein ICP27 can inhibit or augment viral gene transactivation.
A genetic test for expression of a functional herpes simplex virus DNA-binding protein from a transfected plasmid.
"A gene function of herpes simplex virus required for expression of all early viral genes
Authors: Authors: Knipe DM, Batterson W, Roizman B
Animal Virus Genetics"
Animal Virus Genetics"
ATRX promotes maintenance of herpes simplex virus heterochromatin during chromatin stress.
Herpesviral ICP0 Protein Promotes Two Waves of Heterochromatin Removal on an Early Viral Promoter during Lytic Infection.
Identification of TRIM27 as a novel degradation target of herpes simplex virus 1 ICP0.