David Knipe, PhD
Higgins Professor of Microbiology and Molecular Genetics, Harvard Medical School
Identification of a divalent metal cation binding site in herpes simplex virus 1 (HSV-1) ICP8 required for HSV replication.
Herpes simplex virus-1 infection causes the secretion of a type I interferon-antagonizing protein and inhibits signaling at or before Jak-1 activation.
Inhibitors of the sodium potassium ATPase that impair herpes simplex virus replication identified via a chemical screening approach.
Evidence for a direct interaction between HSV-1 ICP27 and ICP8 proteins.
Authors: Authors: Olesky M, McNamee EE, Zhou C, Taylor TJ, Knipe DM.
Virology
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Virology
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Herpes simplex virus replication compartments can form by coalescence of smaller compartments.
Herpes simplex virus-induced keratitis: evaluation of the role of molecular mimicry in lesion pathogenesis.
Authors: Authors: Deshpande SP, Lee S, Zheng M, Song B, Knipe D, Kapp JA, Rouse BT.
J Virol
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J Virol
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Contributions of antibody and T cell subsets to protection elicited by immunization with a replication-defective mutant of herpes simplex virus type 1.
“The replication of herpes simplex virus”
Authors: Authors: Knipe DM
In: Genital and Neonatal Herpes
In: Genital and Neonatal Herpes
Intragenic complementation of herpes simplex virus ICP8 DNA-binding protein mutants.
Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency.
Authors: Authors: Leib DA, Coen DM, Bogard CL, Hicks KA, Yager DR, Knipe DM, Tyler KL, Schaffer PA.
J Virol
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J Virol
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