David Knipe, PhD
Higgins Professor of Microbiology and Molecular Genetics, Harvard Medical School
Replication-defective viruses as vaccines and vaccine vectors.
Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis.
Authors: Authors: Kurt-Jones EA, Chan M, Zhou S, Wang J, Reed G, Bronson R, Arnold MM, Knipe DM, Finberg RW.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Neither LAT nor open reading frame P mutations increase expression of spliced or intron-containing ICP0 transcripts in mouse ganglia latently infected with herpes simplex virus.
Authors: Authors: Chen SH, Lee LY, Garber DA, Schaffer PA, Knipe DM, Coen DM.
J Virol
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J Virol
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Herpes simplex virus infection blocks events in the G1 phase of the cell cycle.
Mechanisms of immunization with a replication-defective mutant of herpes simplex virus 1.
Mechanism of virus-induced Ig subclass shifts.
Genetic evidence for two distinct transactivation functions of the herpes simplex virus alpha protein ICP27.
Genetic studies on murine susceptibility to herpes simplex keratitis.
Authors: Authors: Foster CS, Tsai Y, Monroe JG, Campbell R, Cestari M, Wetzig R, Knipe D, Greene MI.
Clin Immunol Immunopathol
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Clin Immunol Immunopathol
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Characterization of herpes simplex virus 2 temperature-sensitive mutants whose lesions map in or near the coding sequences for the major DNA-binding protein.
Analysis of the defects of temperature-sensitive mutants of vesicular stomatitis virus: intracellular degradation of specific viral proteins.