Donald Coen, PhD
Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
A small molecule exerts selective antiviral activity by targeting the human cytomegalovirus nuclear egress complex
Authors: Authors: Han Chen, Ming F Lye, Christoph Gorgulla, Scott B Ficarro, Gregory D Cuny, David A Scott, Fan Wu, Paul W Rothlauf, Xiaoou Wang, Rosio Fernandez, Jean M Pesola, Sorin Draga, Jarrod A Marto, James M Hogle, Haribabu Arthanari, Donald M Coen
PLoS
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PLoS
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SAMHD1 Modulates Early Steps during Human Cytomegalovirus Infection by Limiting NF-?B Activation.
Authors: Authors: Kim ET, Roche KL, Kulej K, Spruce LA, Seeholzer SH, Coen DM, Diaz-Griffero F, Murphy EA, Weitzman MD.
Cell Rep
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Cell Rep
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History and genomic sequence analysis of the herpes simplex virus 1 KOS and KOS1.1 sub-strains.
Authors: Authors: Colgrove RC, Liu X, Griffiths A, Raja P, Deluca NA, Newman RM, Coen DM, Knipe DM.
Virology
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Virology
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Herpes simplex viruses: mechanisms of DNA replication.
Association of human cytomegalovirus proteins IRS1 and TRS1 with the viral DNA polymerase accessory subunit UL44.
Phosphorylation of retinoblastoma protein by viral protein with cyclin-dependent kinase function.
Authors: Authors: Hume AJ, Finkel JS, Kamil JP, Coen DM, Culbertson MR, Kalejta RF.
Science
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Science
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Herpes simplex virus 1 immediate-early and early gene expression during reactivation from latency under conditions that prevent infectious virus production.
The human cytomegalovirus UL44 protein is a substrate for the UL97 protein kinase.
Authors: Authors: Krosky PM, Baek MC, Jahng WJ, Barrera I, Harvey RJ, Biron KK, Coen DM, Sethna PB.
J Virol
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J Virol
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Quantitation of rare DNAs by PCR.
Human thymidine kinase can functionally replace herpes simplex virus type 1 thymidine kinase for viral replication in mouse sensory ganglia and reactivation from latency upon explant.