Donald Coen, PhD
Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Isolation of foscarnet-resistant human cytomegalovirus patterns of resistance and sensitivity to other antiviral drugs.
Enzymatic activities of overexpressed herpes simplex virus DNA polymerase purified from recombinant baculovirus-infected insect cells.
Authors: Authors: Marcy AI, Olivo PD, Challberg MD, Coen DM.
Nucleic Acids Res
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Nucleic Acids Res
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General aspects of virus drug resistance with special reference to herpes simplex virus.
Mutations in the herpes simplex virus DNA polymerase gene can confer resistance to 9-beta-D-arabinofuranosyladenine.
Potency and Stereoselectivity of Cyclopropavir Triphosphate Action on Human Cytomegalovirus DNA Polymerase.
Authors: Authors: Chen H, Li C, Zemlicka J, Gentry BG, Bowlin TL, Coen DM.
Antimicrob Agents Chemother
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Antimicrob Agents Chemother
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Inactivation of retinoblastoma protein does not overcome the requirement for human cytomegalovirus UL97 in lamina disruption and nuclear egress.
Authors: Authors: Reim NI, Kamil JP, Wang D, Lin A, Sharma M, Ericsson M, Pesola JM, Golan DE, Coen DM.
J Virol
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J Virol
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Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1.
Hopping of a processivity factor on DNA revealed by single-molecule assays of diffusion.
Authors: Authors: Komazin-Meredith G, Mirchev R, Golan DE, van Oijen AM, Coen DM.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Selective anti-cytomegalovirus compounds discovered by screening for inhibitors of subunit interactions of the viral polymerase.
Failure of thymidine kinase-negative herpes simplex virus to reactivate from latency following efficient establishment.