Donald Coen, PhD
Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Role of homodimerization of human cytomegalovirus DNA polymerase accessory protein UL44 in origin-dependent DNA replication in cells.
Authors: Authors: Sinigalia E, Alvisi G, Mercorelli B, Coen DM, Pari GS, Jans DA, Ripalti A, Palù G, Loregian A.
J Virol
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J Virol
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Low-level expression and reversion both contribute to reactivation of herpes simplex virus drug-resistant mutants with mutations on homopolymeric sequences in thymidine kinase.
The herpes simplex virus processivity factor, UL42, binds DNA as a monomer.
Quantitation of rare DNAs by PCR.
Herpes simplex virus processivity factor UL42 imparts increased DNA-binding specificity to the viral DNA polymerase and decreased dissociation from primer-template without reducing the elongation rate.
Temporal regulation of herpes simplex virus type 1 UL24 mRNA expression via differential polyadenylation.
Gene transfer to sensory neurons using herpes virus vectors.
Authors: Authors: Davar G, Kramer MF, Garber D, Roca AL, Andersen JK, Bebrin W, Coen DM, Kosz-Vnenchak M, Knipe DM, Breakefield XO, et al.
Gene Ther
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Gene Ther
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Heterogeneity of a herpes simplex virus clinical isolate exhibiting resistance to acyclovir and foscarnet.
Authors: Authors: Pelosi E, Hicks KA, Sacks SL, Coen DM.
Adv Exp Med Biol
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Adv Exp Med Biol
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Isolation and characterization of herpes simplex virus mutants containing engineered mutations at the DNA polymerase locus.
A genetic approach to promoter recognition during trans induction of viral gene expression.