Donald Coen, PhD

Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Mutations that decrease DNA binding of the processivity factor of the herpes simplex virus DNA polymerase reduce viral yield, alter the kinetics of viral DNA replication, and decrease the fidelity of DNA replication.
Authors: Authors: Jiang C, Hwang YT, Randell JC, Coen DM, Hwang CB.
J Virol
View full abstract on Pubmed
Phosphorylation of the RNA polymerase II carboxyl-terminal domain in human cytomegalovirus-infected cells and in vitro by the viral UL97 protein kinase.
Authors: Authors: Baek MC, Krosky PM, Pearson A, Coen DM.
Virology
View full abstract on Pubmed
Specific phosphorylation of exogenous protein and peptide substrates by the human cytomegalovirus UL97 protein kinase. Importance of the P+5 position.
Authors: Authors: Baek MC, Krosky PM, He Z, Coen DM.
J Biol Chem
View full abstract on Pubmed
A recombinant human cytomegalovirus with a large deletion in UL97 has a severe replication deficiency.
Authors: Authors: Prichard MN, Gao N, Jairath S, Mulamba G, Krosky P, Coen DM, Parker BO, Pari GS.
J Virol
View full abstract on Pubmed
The human cytomegalovirus UL97 protein is a protein kinase that autophosphorylates on serines and threonines.
Authors: Authors: He Z, He YS, Kim Y, Chu L, Ohmstede C, Biron KK, Coen DM.
J Virol
View full abstract on Pubmed
Structural and functional organization of herpes simplex virus DNA polymerase investigated by limited proteolysis.
Authors: Authors: Weisshart K, Kuo AA, Hwang CB, Kumura K, Coen DM.
J Biol Chem
View full abstract on Pubmed
A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells.
Authors: Authors: Sullivan V, Talarico CL, Stanat SC, Davis M, Coen DM, Biron KK.
Nature
View full abstract on Pubmed
Quantitative polymerase chain reaction analysis of herpes simplex virus DNA in ganglia of mice infected with replication-incompetent mutants.
Authors: Authors: Katz JP, Bodin ET, Coen DM.
J Virol
View full abstract on Pubmed
Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition.
Authors: Authors: Gibbs JS, Chiou HC, Bastow KF, Cheng YC, Coen DM.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Fine mapping and molecular cloning of mutations in the herpes simplex virus DNA polymerase locus.
Authors: Authors: Coen DM, Aschman DP, Gelep PT, Retondo MJ, Weller SK, Schaffer PA.
J Virol
View full abstract on Pubmed