Donald Coen, PhD
Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Binding parameters and thermodynamics of the interaction of the human cytomegalovirus DNA polymerase accessory protein, UL44, with DNA: implications for the processivity mechanism.
Authors: Authors: Loregian A, Sinigalia E, Mercorelli B, Palù G, Coen DM.
Nucleic Acids Res
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Nucleic Acids Res
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A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.
Authors: Authors: Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, Kaufman RJ, Ma D, Coen DM, Ron D, Yuan J.
Science
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Science
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The human cytomegalovirus UL97 protein kinase, an antiviral drug target, is required at the stage of nuclear egress.
Persistent elevated expression of cytokine transcripts in ganglia latently infected with herpes simplex virus in the absence of ganglionic replication or reactivation.
Authors: Authors: Chen SH, Garber DA, Schaffer PA, Knipe DM, Coen DM.
Virology
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Virology
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Accumulation of viral transcripts and DNA during establishment of latency by herpes simplex virus.
Specific inhibition of herpes simplex virus DNA polymerase by helical peptides corresponding to the subunit interface.
Authors: Authors: Digard P, Williams KP, Hensley P, Brooks IS, Dahl CE, Coen DM.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Conformational changes induced in herpes simplex virus DNA polymerase upon DNA binding.
Authors: Authors: Weisshart K, Kuo AA, Painter GR, Wright LL, Furman PA, Coen DM.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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The herpes simplex virus type 1 UL42 gene product: a subunit of DNA polymerase that functions to increase processivity.
A conserved open reading frame that overlaps the herpes simplex virus thymidine kinase gene is important for viral growth in cell culture.
Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus.