Donald Coen, PhD
Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Herpesviral latency-associated transcript gene promotes assembly of heterochromatin on viral lytic-gene promoters in latent infection.
Authors: Authors: Wang QY, Zhou C, Johnson KE, Colgrove RC, Coen DM, Knipe DM.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Translational compensation of a frameshift mutation affecting herpes simplex virus thymidine kinase is sufficient to permit reactivation from latency.
Enzymatic amplification of DNA by PCR: standard procedures and optimization.
white+ transgene insertions presenting a dorsal/ventral pattern define a single cluster of homeobox genes that is silenced by the polycomb-group proteins in Drosophila melanogaster.
Authors: Authors: Netter S, Fauvarque MO, Diez del Corral R, Dura JM, Coen D.
Genetics
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Genetics
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Mutations that specifically impair the DNA binding activity of the herpes simplex virus protein UL42.
Evidence for a novel regulatory pathway for herpes simplex virus gene expression in trigeminal ganglion neurons.
Authors: Authors: Kosz-Vnenchak M, Jacobson J, Coen DM, Knipe DM.
J Virol
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J Virol
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The implications of resistance to antiviral agents for herpesvirus drug targets and drug therapy.
Examination of the roles of transcription factor Sp1-binding sites and an octamer motif in trans induction of the herpes simplex virus thymidine kinase gene.
Sequence and mapping analyses of the herpes simplex virus DNA polymerase gene predict a C-terminal substrate binding domain.
Authors: Authors: Gibbs JS, Chiou HC, Hall JD, Mount DW, Retondo MJ, Weller SK, Coen DM.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Differential expression of the gene for the large subunit of ribulose bisphosphate carboxylase in maize leaf cell types.