Donald Coen, PhD

Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
A Small Covalent Allosteric Inhibitor of Human Cytomegalovirus DNA Polymerase Subunit Interactions.
Authors: Authors: Chen H, Coseno M, Ficarro SB, Mansueto MS, Komazin-Meredith G, Boissel S, Filman DJ, Marto JA, Hogle JM, Coen DM.
ACS Infect Dis
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Roles of conserved residues within the pre-NH2-terminal domain of herpes simplex virus 1 DNA polymerase in replication and latency in mice.
Authors: Authors: Terrell SL, Pesola JM, Coen DM.
J Gen Virol
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Sites and roles of phosphorylation of the human cytomegalovirus DNA polymerase subunit UL44.
Authors: Authors: Silva LA, Strang BL, Lin EW, Kamil JP, Coen DM.
Virology
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Biochemical, biophysical, and mutational analyses of subunit interactions of the human cytomegalovirus nuclear egress complex.
Authors: Authors: Sam MD, Evans BT, Coen DM, Hogle JM.
J Virol
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Enzymatic amplification of DNA by PCR: standard procedures and optimization.
Authors: Authors: Kramer MF, Coen DM.
Curr Protoc Cytom
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Identification of a small molecule that inhibits herpes simplex virus DNA Polymerase subunit interactions and viral replication.
Authors: Authors: Pilger BD, Cui C, Coen DM.
Chem Biol
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Neither LAT nor open reading frame P mutations increase expression of spliced or intron-containing ICP0 transcripts in mouse ganglia latently infected with herpes simplex virus.
Authors: Authors: Chen SH, Lee LY, Garber DA, Schaffer PA, Knipe DM, Coen DM.
J Virol
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The enzymological basis for resistance of herpesvirus DNA polymerase mutants to acyclovir: relationship to the structure of alpha-like DNA polymerases.
Authors: Authors: Huang L, Ishii KK, Zuccola H, Gehring AM, Hwang CB, Hogle J, Coen DM.
Proc Natl Acad Sci U S A
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Translational recoding induced by G-rich mRNA sequences that form unusual structures.
Authors: Authors: Horsburgh BC, Kollmus H, Hauser H, Coen DM.
Cell
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A net +1 frameshift permits synthesis of thymidine kinase from a drug-resistant herpes simplex virus mutant.
Authors: Authors: Hwang CB, Horsburgh B, Pelosi E, Roberts S, Digard P, Coen DM.
Proc Natl Acad Sci U S A
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