Donald Coen, PhD
Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Antiviral drug resistance.
Pathogenicity of herpes simplex virus mutants containing drug resistance mutations in the viral DNA polymerase gene.
Acyclovir-resistant mutants of herpes simplex virus type 1 express altered DNA polymerase or reduced acyclovir phosphorylating activities.
Authors: Authors: Furman PA, Coen DM, St Clair MH, Schaffer PA.
J Virol
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J Virol
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A Herpesviral Lytic Protein Regulates the Structure of Latent Viral Chromatin.
Authors: Authors: Raja P, Lee JS, Pan D, Pesola JM, Coen DM, Knipe DM.
MBio
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MBio
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Kinetics of facultative heterochromatin and polycomb group protein association with the herpes simplex viral genome during establishment of latent infection.
Stereoselective phosphorylation of cyclopropavir by pUL97 and competitive inhibition by maribavir.
Authors: Authors: Gentry BG, Kamil JP, Coen DM, Zemlicka J, Drach JC.
Antimicrob Agents Chemother
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Antimicrob Agents Chemother
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MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs.
Authors: Authors: Umbach JL, Kramer MF, Jurak I, Karnowski HW, Coen DM, Cullen BR.
Nature
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Nature
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Crystal structure of the cytomegalovirus DNA polymerase subunit UL44 in complex with the C terminus from the catalytic subunit. Differences in structure and function relative to unliganded UL44.
Authors: Authors: Appleton BA, Brooks J, Loregian A, Filman DJ, Coen DM, Hogle JM.
J Biol Chem
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J Biol Chem
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Latent herpes simplex virus infection of sensory neurons alters neuronal gene expression.
Authors: Authors: Kramer MF, Cook WJ, Roth FP, Zhu J, Holman H, Knipe DM, Coen DM.
J Virol
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J Virol
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Identification of crucial hydrogen-bonding residues for the interaction of herpes simplex virus DNA polymerase subunits via peptide display, mutational, and calorimetric approaches.