Donald Coen, PhD

Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Mutations that decrease DNA binding of the processivity factor of the herpes simplex virus DNA polymerase reduce viral yield, alter the kinetics of viral DNA replication, and decrease the fidelity of DNA replication.
Authors: Authors: Jiang C, Hwang YT, Randell JC, Coen DM, Hwang CB.
J Virol
View full abstract on Pubmed
Phosphorylation of the RNA polymerase II carboxyl-terminal domain in human cytomegalovirus-infected cells and in vitro by the viral UL97 protein kinase.
Authors: Authors: Baek MC, Krosky PM, Pearson A, Coen DM.
Virology
View full abstract on Pubmed
Specific phosphorylation of exogenous protein and peptide substrates by the human cytomegalovirus UL97 protein kinase. Importance of the P+5 position.
Authors: Authors: Baek MC, Krosky PM, He Z, Coen DM.
J Biol Chem
View full abstract on Pubmed
A recombinant human cytomegalovirus with a large deletion in UL97 has a severe replication deficiency.
Authors: Authors: Prichard MN, Gao N, Jairath S, Mulamba G, Krosky P, Coen DM, Parker BO, Pari GS.
J Virol
View full abstract on Pubmed
The human cytomegalovirus UL97 protein is a protein kinase that autophosphorylates on serines and threonines.
Authors: Authors: He Z, He YS, Kim Y, Chu L, Ohmstede C, Biron KK, Coen DM.
J Virol
View full abstract on Pubmed
Structural and functional organization of herpes simplex virus DNA polymerase investigated by limited proteolysis.
Authors: Authors: Weisshart K, Kuo AA, Hwang CB, Kumura K, Coen DM.
J Biol Chem
View full abstract on Pubmed
A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells.
Authors: Authors: Sullivan V, Talarico CL, Stanat SC, Davis M, Coen DM, Biron KK.
Nature
View full abstract on Pubmed
Specific inhibitors of herpes simplex virus thymidine kinase diminish reactivation of latent virus from explanted murine ganglia.
Authors: Authors: Leib DA, Ruffner KL, Hildebrand C, Schaffer PA, Wright GE, Coen DM.
Antimicrob Agents Chemother
View full abstract on Pubmed
Analysis of the transcript of the herpes simplex virus DNA polymerase gene provides evidence that polymerase expression is inefficient at the level of translation.
Authors: Authors: Yager DR, Coen DM.
J Virol
View full abstract on Pubmed
Genetic analysis of temperature-sensitive mutants of HSV-1: the combined use of complementation and physical mapping for cistron assignment.
Authors: Authors: Weller SK, Aschman DP, Sacks WR, Coen DM, Schaffer PA.
Virology
View full abstract on Pubmed