Donald Coen, PhD
Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Enzymatic amplification of DNA by PCR: standard procedures and optimization.
The role of herpes simplex virus ICP27 in the regulation of UL24 gene expression by differential polyadenylation.
Authors: Authors: Hann LE, Cook WJ, Uprichard SL, Knipe DM, Coen DM.
J Virol
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J Virol
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Antiviral drug resistance in herpes simplex virus.
The herpes simplex virus type 1 regulatory protein ICP0 enhances virus replication during acute infection and reactivation from latency.
Authors: Authors: Cai W, Astor TL, Liptak LM, Cho C, Coen DM, Schaffer PA.
J Virol
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J Virol
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Polymerization activity of an alpha-like DNA polymerase requires a conserved 3'-5' exonuclease active site.
Authors: Authors: Gibbs JS, Weisshart K, Digard P, deBruynKops A, Knipe DM, Coen DM.
Mol Cell Biol
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Mol Cell Biol
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Antiviral drug resistance.
Pathogenicity of herpes simplex virus mutants containing drug resistance mutations in the viral DNA polymerase gene.
Acyclovir-resistant mutants of herpes simplex virus type 1 express altered DNA polymerase or reduced acyclovir phosphorylating activities.
Authors: Authors: Furman PA, Coen DM, St Clair MH, Schaffer PA.
J Virol
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J Virol
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A Herpesviral Lytic Protein Regulates the Structure of Latent Viral Chromatin.
Authors: Authors: Raja P, Lee JS, Pan D, Pesola JM, Coen DM, Knipe DM.
MBio
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MBio
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Kinetics of facultative heterochromatin and polycomb group protein association with the herpes simplex viral genome during establishment of latent infection.