Donald Coen, PhD

Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Herpes simplex virus mutants with multiple substitutions affecting DNA binding of UL42 are impaired for viral replication and DNA synthesis.
Authors: Authors: Jiang C, Hwang YT, Wang G, Randell JC, Coen DM, Hwang CB.
J Virol
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Effects of substitutions of arginine residues on the basic surface of herpes simplex virus UL42 support a role for DNA binding in processive DNA synthesis.
Authors: Authors: Randell JC, Komazin G, Jiang C, Hwang CB, Coen DM.
J Virol
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Effect of immunization on herpes simplex virus type 1 latent infection in the trigeminal ganglion.
Authors: Authors: Kramer M, Riley J, Spoering A, Coen D, Knipe D.
Curr Eye Res
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Enzymatic amplification of DNA by PCR: standard procedures and optimization.
Authors: Authors: Kramer MF, Coen DM.
Curr Protoc Cell Biol
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The persistence of (HIV in) memory (T cells).
Authors: Authors: Coen DM.
Trends Microbiol
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Molecular mechanisms of antiviral resistance.
Authors: Authors: Kimberlin DW, Coen DM, Biron KK, Cohen JI, Lamb RA, McKinlay M, Emini EA, Whitley RJ.
Antiviral Res
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Reduction and elimination of encephalitis in an experimental glioma therapy model with attenuated herpes simplex mutants that retain susceptibility to acyclovir.
Authors: Authors: Markert JM, Malick A, Coen DM, Martuza RL.
Neurosurgery
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Herpes simplex virus transactivator ICP4 operationally substitutes for the cellular transcription factor Sp1 for efficient expression of the viral thymidine kinase gene.
Authors: Authors: Imbalzano AN, Coen DM, DeLuca NA.
J Virol
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A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency.
Authors: Authors: Leib DA, Bogard CL, Kosz-Vnenchak M, Hicks KA, Coen DM, Knipe DM, Schaffer PA.
J Virol
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Promoter domains required for expression of plasmid-borne copies of the herpes simplex virus thymidine kinase gene in virus-infected mouse fibroblasts and microinjected frog oocytes.
Authors: Authors: Eisenberg SP, Coen DM, McKnight SL.
Mol Cell Biol
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