Donald Coen, PhD

Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Stereoselective phosphorylation of cyclopropavir by pUL97 and competitive inhibition by maribavir.
Authors: Authors: Gentry BG, Kamil JP, Coen DM, Zemlicka J, Drach JC.
Antimicrob Agents Chemother
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MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs.
Authors: Authors: Umbach JL, Kramer MF, Jurak I, Karnowski HW, Coen DM, Cullen BR.
Nature
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Crystal structure of the cytomegalovirus DNA polymerase subunit UL44 in complex with the C terminus from the catalytic subunit. Differences in structure and function relative to unliganded UL44.
Authors: Authors: Appleton BA, Brooks J, Loregian A, Filman DJ, Coen DM, Hogle JM.
J Biol Chem
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Latent herpes simplex virus infection of sensory neurons alters neuronal gene expression.
Authors: Authors: Kramer MF, Cook WJ, Roth FP, Zhu J, Holman H, Knipe DM, Coen DM.
J Virol
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Identification of crucial hydrogen-bonding residues for the interaction of herpes simplex virus DNA polymerase subunits via peptide display, mutational, and calorimetric approaches.
Authors: Authors: Bridges KG, Chow CS, Coen DM.
J Virol
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Recurrent acyclovir-resistant herpes simplex in an immunocompromised patient: can strain differences compensate for loss of thymidine kinase in pathogenesis?
Authors: Authors: Horsburgh BC, Chen SH, Hu A, Mulamba GB, Burns WH, Coen DM.
J Infect Dis
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Prevalence of localized rearrangements vs. transpositions among events induced by Drosophila P element transposase on a P transgene.
Authors: Authors: Delattre M, Anxolabéhère D, Coen D.
Genetics
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Herpes simplex virus thymidine kinase and specific stages of latency in murine trigeminal ganglia.
Authors: Authors: Jacobson JG, Ruffner KL, Kosz-Vnenchak M, Hwang CB, Wobbe KK, Knipe DM, Coen DM.
J Virol
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P regulatory products repress in vivo the P promoter activity in P-lacZ fusion genes.
Authors: Authors: Lemaitre B, Coen D.
Proc Natl Acad Sci U S A
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Progressive esophagitis from acyclovir-resistant herpes simplex. Clinical roles for DNA polymerase mutants and viral heterogeneity?
Authors: Authors: Sacks SL, Wanklin RJ, Reece DE, Hicks KA, Tyler KL, Coen DM.
Ann Intern Med
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