Donald Coen, PhD
Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Association of human cytomegalovirus proteins IRS1 and TRS1 with the viral DNA polymerase accessory subunit UL44.
Phosphorylation of retinoblastoma protein by viral protein with cyclin-dependent kinase function.
Authors: Authors: Hume AJ, Finkel JS, Kamil JP, Coen DM, Culbertson MR, Kalejta RF.
Science
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Science
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Herpes simplex virus 1 immediate-early and early gene expression during reactivation from latency under conditions that prevent infectious virus production.
The human cytomegalovirus UL44 protein is a substrate for the UL97 protein kinase.
Authors: Authors: Krosky PM, Baek MC, Jahng WJ, Barrera I, Harvey RJ, Biron KK, Coen DM, Sethna PB.
J Virol
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J Virol
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Quantitation of rare DNAs by PCR.
Human thymidine kinase can functionally replace herpes simplex virus type 1 thymidine kinase for viral replication in mouse sensory ganglia and reactivation from latency upon explant.
Initiator elements and regulated expression of the herpes simplex virus thymidine kinase gene.
Demonstration of circularization of herpes simplex virus DNA following infection using pulsed field gel electrophoresis.
Experimental therapy of human glioma by means of a genetically engineered virus mutant.
Authors: Authors: Martuza RL, Malick A, Markert JM, Ruffner KL, Coen DM.
Science
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Science
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A herpes simplex virus ribonucleotide reductase deletion mutant is defective for productive acute and reactivatable latent infections of mice and for replication in mouse cells.
Authors: Authors: Jacobson JG, Leib DA, Goldstein DJ, Bogard CL, Schaffer PA, Weller SK, Coen DM.
Virology
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Virology
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