Donald Coen, PhD
Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Inhibitors of the sodium potassium ATPase that impair herpes simplex virus replication identified via a chemical screening approach.
Persistent expression of chemokine and chemokine receptor RNAs at primary and latent sites of herpes simplex virus 1 infection.
Authors: Authors: Cook WJ, Kramer MF, Walker RM, Burwell TJ, Holman HA, Coen DM, Knipe DM.
Virol J
View full abstract on Pubmed
Virol J
View full abstract on Pubmed
Relationship between autophosphorylation and phosphorylation of exogenous substrates by the human cytomegalovirus UL97 protein kinase.
The crystal structure of an unusual processivity factor, herpes simplex virus UL42, bound to the C terminus of its cognate polymerase.
Penciclovir and pathogenesis phenotypes of drug-resistant Herpes simplex virus mutants.
Synergistic effects on ganglionic herpes simplex virus infections by mutations or drugs that inhibit the viral polymerase and thymidine kinase.
Authors: Authors: Jacobson J, Kramer M, Rozenberg F, Hu A, Coen DM.
Virology
View full abstract on Pubmed
Virology
View full abstract on Pubmed
A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivatives.
Authors: Authors: Sullivan V, Biron KK, Talarico C, Stanat SC, Davis M, Pozzi LM, Coen DM.
Antimicrob Agents Chemother
View full abstract on Pubmed
Antimicrob Agents Chemother
View full abstract on Pubmed
P element regulatory products enhance zeste repression of a P[white duplicated] transgene in Drosophila melanogaster.
Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency.
Authors: Authors: Leib DA, Coen DM, Bogard CL, Hicks KA, Yager DR, Knipe DM, Tyler KL, Schaffer PA.
J Virol
View full abstract on Pubmed
J Virol
View full abstract on Pubmed
Herpes simplex virus mutants resistant to arabinosyladenine in the presence of deoxycoformycin.