Douglas Melton, PhD
Xander University Professor of Stem Cell and Regenerative Biology, Faculty of Arts & Sciences
A Nutrient-Sensing Transition at Birth Triggers Glucose-Responsive Insulin Secretion.
Authors: Authors: Helman A, Cangelosi AL, Davis JC, Pham Q, Rothman A, Faust AL, Straubhaar JR, Sabatini DM, Melton DA.
Cell Metab
View full abstract on Pubmed
Cell Metab
View full abstract on Pubmed
Apolipoprotein E is a pancreatic extracellular factor that maintains mature ß-cell gene expression.
Authors: Authors: Mahmoud AI, Galdos FX, Dinan KA, Jedrychowski MP, Davis JC, Vujic A, Rachmin I, Shigley C, Pancoast JR, Lee S, Hollister-Lock J, MacGillivray CM, Gygi SP, Melton DA, Weir GC, Lee RT.
PLoS One
View full abstract on Pubmed
PLoS One
View full abstract on Pubmed
Differentiated human stem cells resemble fetal, not adult, ß cells.
Authors: Authors: Hrvatin S, O'Donnell CW, Deng F, Millman JR, Pagliuca FW, DiIorio P, Rezania A, Gifford DK, Melton DA.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Proc Natl Acad Sci U S A
View full abstract on Pubmed
How to make beta cells?
Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver.
Notch signaling controls multiple steps of pancreatic differentiation.
Authors: Authors: Murtaugh LC, Stanger BZ, Kwan KM, Melton DA.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Development of the pancreas in Xenopus laevis.
A molecular mechanism for the effect of lithium on development.
Processed Vg1 protein is an axial mesoderm inducer in Xenopus.
A two-step model for the localization of maternal mRNA in Xenopus oocytes: involvement of microtubules and microfilaments in the translocation and anchoring of Vg1 mRNA.