Ed Harlow

Ed Harlow, PhD

Virginia and D.K. Ludwig Professor of Cancer Research and Teaching, Harvard Medical School

Dr. Edward (Ed) E. Harlow, Jr. Ph.D. is a distinguished molecular biologist and an internationally recognized leader in cancer biology, who is best known for his discoveries regarding the control of cell division and critical changes that allow cancer to develop.  He currently splits his time between an appointment as Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School and Senior Advisor to the Director, National Cancer Institute.  He served as Chief Scientific Officer of Constellation Pharmaceuticals, Inc. from 2009 to 2011.  From 1998 to 2009, he served as Professor and Chair of the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School and was Associate Director of the Dana-Farber/Harvard Cancer Center.  From 1990 to 1998, he served as Scientific Director for the Massachusetts General Hospital Cancer Center and was Associate Director for Science Policy at the National Cancer Institute, where he helped direct U.S. cancer research planning.  Prior to 1990, Dr. Harlow served on the faculty of Cold Spring Harbor Laboratory.  Dr. Harlow has served on a number of influential advisory groups, including the Board of Life Sciences for the National Research Council, External Advisory Boards for UCSF, Stanford, UCLA, and NYU Cancer Centers and the Scientific Advisory Board for the Foundation for Advanced Cancer Studies.  He has chaired or served on numerous biotechnology and pharmaceutical companies advisory boards, including Onyx, 3V Biosciences, Alnylam, and Pfizer Pharmaceuticals. Dr. Harlow has received numerous scientific honors, including election to the National Academy of Sciences in 1993 and the Institute of Medicine in 1999, appointment as Fellow of the American Academy of Arts and Sciences, and recipient of the American Cancer Society's highest award, the Medal of Honor. Dr. Harlow with Dr. David Lane are co-authors of one of the all time best-selling research manuals, Antibodies: A laboratory manual.  Dr. Harlow received his B.S. and M.S. from the University of Oklahoma and his Ph.D. at the Imperial Cancer Research Fund in London in 1982.

GRK3 is essential for metastatic cells and promotes prostate tumor progression.
Authors: Authors: Li W, Ai N, Wang S, Bhattacharya N, Vrbanac V, Collins M, Signoretti S, Hu Y, Boyce FM, Gravdal K, Halvorsen OJ, Nalwoga H, Akslen LA, Harlow E, Watnick RS.
Proc Natl Acad Sci U S A
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A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation.
Authors: Authors: Johnson BR, Nitta RT, Frock RL, Mounkes L, Barbie DA, Stewart CL, Harlow E, Kennedy BK.
Proc Natl Acad Sci U S A
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No effect of loss of E2F1 on liver regeneration or hepatocarcinogenesis in C57BL/6J or C3H/HeJ mice.
Authors: Authors: Lukas ER, Bartley SM, Graveel CR, Diaz ZM, Dyson N, Harlow E, Yamasaki L, Farnham PJ.
Mol Carcinog
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Expression of the retinoblastoma protein in low-grade B-cell lymphoma: relationship to cyclin D1.
Authors: Authors: Zukerberg LR, Benedict WF, Arnold A, Dyson N, Harlow E, Harris NL.
Blood
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Growth suppression by members of the retinoblastoma protein family.
Authors: Authors: Zhu L, Enders GH, Wu CL, Starz MA, Moberg KH, Lees JA, Dyson N, Harlow E.
Cold Spring Harb Symp Quant Biol
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A family of human cdc2-related protein kinases.
Authors: Authors: Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH.
EMBO J
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Cloning and expression of a mammalian peptide chain release factor with sequence similarity to tryptophanyl-tRNA synthetases.
Authors: Authors: Lee CC, Craigen WJ, Muzny DM, Harlow E, Caskey CT.
Proc Natl Acad Sci U S A
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Polyomavirus small t antigen: overproduction in bacteria, purification, and utilization for monoclonal and polyclonal antibody production.
Authors: Authors: Pallas DC, Schley C, Mahoney M, Harlow E, Schaffhausen BS, Roberts TM.
J Virol
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Evaluation of Tyro3 expression, Gas6-mediated Akt phosphorylation, and the impact of anti-Tyro3 antibodies in melanoma cell lines.
Authors: Authors: Demarest SJ, Gardner J, Vendel MC, Ailor E, Szak S, Huang F, Doern A, Tan X, Yang W, Grueneberg DA, Richards EJ, Endege WO, Harlow E, Koopman LA.
Biochemistry
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Nuclear reorganization of mammalian DNA synthesis prior to cell cycle exit.
Authors: Authors: Barbie DA, Kudlow BA, Frock R, Zhao J, Johnson BR, Dyson N, Harlow E, Kennedy BK.
Mol Cell Biol
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