Ed Harlow

Ed Harlow, PhD

Virginia and D.K. Ludwig Professor of Cancer Research and Teaching, Harvard Medical School

Dr. Edward (Ed) E. Harlow, Jr. Ph.D. is a distinguished molecular biologist and an internationally recognized leader in cancer biology, who is best known for his discoveries regarding the control of cell division and critical changes that allow cancer to develop.  He currently splits his time between an appointment as Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School and Senior Advisor to the Director, National Cancer Institute.  He served as Chief Scientific Officer of Constellation Pharmaceuticals, Inc. from 2009 to 2011.  From 1998 to 2009, he served as Professor and Chair of the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School and was Associate Director of the Dana-Farber/Harvard Cancer Center.  From 1990 to 1998, he served as Scientific Director for the Massachusetts General Hospital Cancer Center and was Associate Director for Science Policy at the National Cancer Institute, where he helped direct U.S. cancer research planning.  Prior to 1990, Dr. Harlow served on the faculty of Cold Spring Harbor Laboratory.  Dr. Harlow has served on a number of influential advisory groups, including the Board of Life Sciences for the National Research Council, External Advisory Boards for UCSF, Stanford, UCLA, and NYU Cancer Centers and the Scientific Advisory Board for the Foundation for Advanced Cancer Studies.  He has chaired or served on numerous biotechnology and pharmaceutical companies advisory boards, including Onyx, 3V Biosciences, Alnylam, and Pfizer Pharmaceuticals. Dr. Harlow has received numerous scientific honors, including election to the National Academy of Sciences in 1993 and the Institute of Medicine in 1999, appointment as Fellow of the American Academy of Arts and Sciences, and recipient of the American Cancer Society's highest award, the Medal of Honor. Dr. Harlow with Dr. David Lane are co-authors of one of the all time best-selling research manuals, Antibodies: A laboratory manual.  Dr. Harlow received his B.S. and M.S. from the University of Oklahoma and his Ph.D. at the Imperial Cancer Research Fund in London in 1982.

Cyclin-dependent kinases: a family portrait.
Authors: Authors: Malumbres M, Harlow E, Hunt T, Hunter T, Lahti JM, Manning G, Morgan DO, Tsai LH, Wolgemuth DJ.
Nat Cell Biol
View full abstract on Pubmed
RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest.
Authors: Authors: Lai A, Kennedy BK, Barbie DA, Bertos NR, Yang XJ, Theberge MC, Tsai SC, Seto E, Zhang Y, Kuzmichev A, Lane WS, Reinberg D, Harlow E, Branton PE.
Mol Cell Biol
View full abstract on Pubmed
New functional activities for the p21 family of CDK inhibitors.
Authors: Authors: LaBaer J, Garrett MD, Stevenson LF, Slingerland JM, Sandhu C, Chou HS, Fattaey A, Harlow E.
Genes Dev
View full abstract on Pubmed
The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes.
Authors: Authors: Zhu L, Enders G, Lees JA, Beijersbergen RL, Bernards R, Harlow E.
EMBO J
View full abstract on Pubmed
Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein.
Authors: Authors: Helin K, Harlow E, Fattaey A.
Mol Cell Biol
View full abstract on Pubmed
Adenovirus E1A targets key regulators of cell proliferation.
Authors: Authors: Dyson N, Harlow E.
Cancer Surv
View full abstract on Pubmed
Point mutational inactivation of the retinoblastoma antioncogene.
Authors: Authors: Horowitz JM, Yandell DW, Park SH, Canning S, Whyte P, Buchkovich K, Harlow E, Weinberg RA, Dryja TP.
Science
View full abstract on Pubmed
Kinase requirements in human cells: III. Altered kinase requirements in VHL-/- cancer cells detected in a pilot synthetic lethal screen.
Authors: Authors: Bommi-Reddy A, Almeciga I, Sawyer J, Geisen C, Li W, Harlow E, Kaelin WG, Grueneberg DA.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
A large-scale overexpression screen in Saccharomyces cerevisiae identifies previously uncharacterized cell cycle genes.
Authors: Authors: Stevenson LF, Kennedy BK, Harlow E.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway.
Authors: Authors: Goillot E, Raingeaud J, Ranger A, Tepper RI, Davis RJ, Harlow E, Sanchez I.
Proc Natl Acad Sci U S A
View full abstract on Pubmed