Ed Harlow

Ed Harlow, PhD

Virginia and D.K. Ludwig Professor of Cancer Research and Teaching, Harvard Medical School

Dr. Edward (Ed) E. Harlow, Jr. Ph.D. is a distinguished molecular biologist and an internationally recognized leader in cancer biology, who is best known for his discoveries regarding the control of cell division and critical changes that allow cancer to develop.  He currently splits his time between an appointment as Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School and Senior Advisor to the Director, National Cancer Institute.  He served as Chief Scientific Officer of Constellation Pharmaceuticals, Inc. from 2009 to 2011.  From 1998 to 2009, he served as Professor and Chair of the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School and was Associate Director of the Dana-Farber/Harvard Cancer Center.  From 1990 to 1998, he served as Scientific Director for the Massachusetts General Hospital Cancer Center and was Associate Director for Science Policy at the National Cancer Institute, where he helped direct U.S. cancer research planning.  Prior to 1990, Dr. Harlow served on the faculty of Cold Spring Harbor Laboratory.  Dr. Harlow has served on a number of influential advisory groups, including the Board of Life Sciences for the National Research Council, External Advisory Boards for UCSF, Stanford, UCLA, and NYU Cancer Centers and the Scientific Advisory Board for the Foundation for Advanced Cancer Studies.  He has chaired or served on numerous biotechnology and pharmaceutical companies advisory boards, including Onyx, 3V Biosciences, Alnylam, and Pfizer Pharmaceuticals. Dr. Harlow has received numerous scientific honors, including election to the National Academy of Sciences in 1993 and the Institute of Medicine in 1999, appointment as Fellow of the American Academy of Arts and Sciences, and recipient of the American Cancer Society's highest award, the Medal of Honor. Dr. Harlow with Dr. David Lane are co-authors of one of the all time best-selling research manuals, Antibodies: A laboratory manual.  Dr. Harlow received his B.S. and M.S. from the University of Oklahoma and his Ph.D. at the Imperial Cancer Research Fund in London in 1982.

Heterodimerization of the transcription factors E2F-1 and DP-1 is required for binding to the adenovirus E4 (ORF6/7) protein.
Authors: Authors: Helin K, Harlow E.
J Virol
View full abstract on Pubmed
Sequences within the conserved cyclin box of human cyclin A are sufficient for binding to and activation of cdc2 kinase.
Authors: Authors: Lees EM, Harlow E.
Mol Cell Biol
View full abstract on Pubmed
Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase.
Authors: Authors: Tsai LH, Harlow E, Meyerson M.
Nature
View full abstract on Pubmed
Two regions of the adenovirus early region 1A proteins are required for transformation.
Authors: Authors: Whyte P, Ruley HE, Harlow E.
J Virol
View full abstract on Pubmed
Building a human kinase gene repository: bioinformatics, molecular cloning, and functional validation.
Authors: Authors: Park J, Hu Y, Murthy TV, Vannberg F, Shen B, Rolfs A, Hutti JE, Cantley LC, Labaer J, Harlow E, Brizuela L.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription.
Authors: Authors: Zhao J, Kennedy BK, Lawrence BD, Barbie DA, Matera AG, Fletcher JA, Harlow E.
Genes Dev
View full abstract on Pubmed
A research shortcut from a common cold virus to human cancer.
Authors: Authors: Harlow E.
Cancer
View full abstract on Pubmed
Differential regulation of E2F transactivation by cyclin/cdk2 complexes.
Authors: Authors: Dynlacht BD, Flores O, Lees JA, Harlow E.
Genes Dev
View full abstract on Pubmed
Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins.
Authors: Authors: Dyson N, Guida P, Münger K, Harlow E.
J Virol
View full abstract on Pubmed
Polyomavirus large T mutants affected in retinoblastoma protein binding are defective in immortalization.
Authors: Authors: Larose A, Dyson N, Sullivan M, Harlow E, Bastin M.
J Virol
View full abstract on Pubmed