Ed Harlow

Ed Harlow, PhD

Virginia and D.K. Ludwig Professor of Cancer Research and Teaching, Harvard Medical School

Dr. Edward (Ed) E. Harlow, Jr. Ph.D. is a distinguished molecular biologist and an internationally recognized leader in cancer biology, who is best known for his discoveries regarding the control of cell division and critical changes that allow cancer to develop.  He currently splits his time between an appointment as Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School and Senior Advisor to the Director, National Cancer Institute.  He served as Chief Scientific Officer of Constellation Pharmaceuticals, Inc. from 2009 to 2011.  From 1998 to 2009, he served as Professor and Chair of the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School and was Associate Director of the Dana-Farber/Harvard Cancer Center.  From 1990 to 1998, he served as Scientific Director for the Massachusetts General Hospital Cancer Center and was Associate Director for Science Policy at the National Cancer Institute, where he helped direct U.S. cancer research planning.  Prior to 1990, Dr. Harlow served on the faculty of Cold Spring Harbor Laboratory.  Dr. Harlow has served on a number of influential advisory groups, including the Board of Life Sciences for the National Research Council, External Advisory Boards for UCSF, Stanford, UCLA, and NYU Cancer Centers and the Scientific Advisory Board for the Foundation for Advanced Cancer Studies.  He has chaired or served on numerous biotechnology and pharmaceutical companies advisory boards, including Onyx, 3V Biosciences, Alnylam, and Pfizer Pharmaceuticals. Dr. Harlow has received numerous scientific honors, including election to the National Academy of Sciences in 1993 and the Institute of Medicine in 1999, appointment as Fellow of the American Academy of Arts and Sciences, and recipient of the American Cancer Society's highest award, the Medal of Honor. Dr. Harlow with Dr. David Lane are co-authors of one of the all time best-selling research manuals, Antibodies: A laboratory manual.  Dr. Harlow received his B.S. and M.S. from the University of Oklahoma and his Ph.D. at the Imperial Cancer Research Fund in London in 1982.

Distinct roles for cyclin-dependent kinases in cell cycle control.
Authors: Authors: van den Heuvel S, Harlow E.
Science
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Adenovirus E1A makes two distinct contacts with the retinoblastoma protein.
Authors: Authors: Dyson N, Guida P, McCall C, Harlow E.
J Virol
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Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein.
Authors: Authors: Dyson N, Bernards R, Friend SH, Gooding LR, Hassell JA, Major EO, Pipas JM, Vandyke T, Harlow E.
J Virol
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Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53.
Authors: Authors: Harlow E, Williamson NM, Ralston R, Helfman DM, Adams TE.
Mol Cell Biol
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High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy.
Authors: Authors: Gonzalez-Malerva L, Park J, Zou L, Hu Y, Moradpour Z, Pearlberg J, Sawyer J, Stevens H, Harlow E, LaBaer J.
Proc Natl Acad Sci U S A
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The retinoblastoma tumour suppressor in development and cancer.
Authors: Authors: Classon M, Harlow E.
Nat Rev Cancer
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Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A.
Authors: Authors: Schulman BA, Lindstrom DL, Harlow E.
Proc Natl Acad Sci U S A
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Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1.
Authors: Authors: Wu CL, Classon M, Dyson N, Harlow E.
Mol Cell Biol
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Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes.
Authors: Authors: Fattaey AR, Harlow E, Helin K.
Mol Cell Biol
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Eleventh annual Sapporo Cancer Seminar. Connecting the dots: assembling the pathways that control cell division.
Authors: Authors: Harlow E.
Cancer Res
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