Ed Harlow

Ed Harlow, PhD

Virginia and D.K. Ludwig Professor of Cancer Research and Teaching, Harvard Medical School

Dr. Edward (Ed) E. Harlow, Jr. Ph.D. is a distinguished molecular biologist and an internationally recognized leader in cancer biology, who is best known for his discoveries regarding the control of cell division and critical changes that allow cancer to develop.  He currently splits his time between an appointment as Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School and Senior Advisor to the Director, National Cancer Institute.  He served as Chief Scientific Officer of Constellation Pharmaceuticals, Inc. from 2009 to 2011.  From 1998 to 2009, he served as Professor and Chair of the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School and was Associate Director of the Dana-Farber/Harvard Cancer Center.  From 1990 to 1998, he served as Scientific Director for the Massachusetts General Hospital Cancer Center and was Associate Director for Science Policy at the National Cancer Institute, where he helped direct U.S. cancer research planning.  Prior to 1990, Dr. Harlow served on the faculty of Cold Spring Harbor Laboratory.  Dr. Harlow has served on a number of influential advisory groups, including the Board of Life Sciences for the National Research Council, External Advisory Boards for UCSF, Stanford, UCLA, and NYU Cancer Centers and the Scientific Advisory Board for the Foundation for Advanced Cancer Studies.  He has chaired or served on numerous biotechnology and pharmaceutical companies advisory boards, including Onyx, 3V Biosciences, Alnylam, and Pfizer Pharmaceuticals. Dr. Harlow has received numerous scientific honors, including election to the National Academy of Sciences in 1993 and the Institute of Medicine in 1999, appointment as Fellow of the American Academy of Arts and Sciences, and recipient of the American Cancer Society's highest award, the Medal of Honor. Dr. Harlow with Dr. David Lane are co-authors of one of the all time best-selling research manuals, Antibodies: A laboratory manual.  Dr. Harlow received his B.S. and M.S. from the University of Oklahoma and his Ph.D. at the Imperial Cancer Research Fund in London in 1982.

Cellular targets for transformation by the adenovirus E1A proteins.
Authors: Authors: Whyte P, Williamson NM, Harlow E.
Cell
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Kinase requirements in human cells: II. Genetic interaction screens identify kinase requirements following HPV16 E7 expression in cancer cells.
Authors: Authors: Baldwin A, Li W, Grace M, Pearlberg J, Harlow E, Münger K, Grueneberg DA.
Proc Natl Acad Sci U S A
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Nuclear organization of DNA replication in primary mammalian cells.
Authors: Authors: Kennedy BK, Barbie DA, Classon M, Dyson N, Harlow E.
Genes Dev
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Purification and analysis of CIP/KIP proteins.
Authors: Authors: Dynlacht BD, Ngwu C, Winston J, Swindell EC, Elledge SJ, Harlow E, Harper JW.
Methods Enzymol
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Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line.
Authors: Authors: Saito M, Helin K, Valentine MB, Griffith BB, Willman CL, Harlow E, Look AT.
Genomics
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The cdk2 kinase is required for the G1-to-S transition in mammalian cells.
Authors: Authors: Tsai LH, Lees E, Faha B, Harlow E, Riabowol K.
Oncogene
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Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides.
Authors: Authors: Hu QJ, Bautista C, Edwards GM, Defeo-Jones D, Jones RE, Harlow E.
Mol Cell Biol
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Cellular proteins that are targetted by DNA tumor viruses for transformation.
Authors: Authors: Dyson N, Buchkovich K, Whyte P, Harlow E.
Princess Takamatsu Symp
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Kinase requirements in human cells: I. Comparing kinase requirements across various cell types.
Authors: Authors: Grueneberg DA, Degot S, Pearlberg J, Li W, Davies JE, Baldwin A, Endege W, Doench J, Sawyer J, Hu Y, Boyce F, Xian J, Munger K, Harlow E.
Proc Natl Acad Sci U S A
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Opposing roles of pRB and p107 in adipocyte differentiation.
Authors: Authors: Classon M, Kennedy BK, Mulloy R, Harlow E.
Proc Natl Acad Sci U S A
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