Ed Harlow

Ed Harlow, PhD

Virginia and D.K. Ludwig Professor of Cancer Research and Teaching, Harvard Medical School

Dr. Edward (Ed) E. Harlow, Jr. Ph.D. is a distinguished molecular biologist and an internationally recognized leader in cancer biology, who is best known for his discoveries regarding the control of cell division and critical changes that allow cancer to develop.  He currently splits his time between an appointment as Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School and Senior Advisor to the Director, National Cancer Institute.  He served as Chief Scientific Officer of Constellation Pharmaceuticals, Inc. from 2009 to 2011.  From 1998 to 2009, he served as Professor and Chair of the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School and was Associate Director of the Dana-Farber/Harvard Cancer Center.  From 1990 to 1998, he served as Scientific Director for the Massachusetts General Hospital Cancer Center and was Associate Director for Science Policy at the National Cancer Institute, where he helped direct U.S. cancer research planning.  Prior to 1990, Dr. Harlow served on the faculty of Cold Spring Harbor Laboratory.  Dr. Harlow has served on a number of influential advisory groups, including the Board of Life Sciences for the National Research Council, External Advisory Boards for UCSF, Stanford, UCLA, and NYU Cancer Centers and the Scientific Advisory Board for the Foundation for Advanced Cancer Studies.  He has chaired or served on numerous biotechnology and pharmaceutical companies advisory boards, including Onyx, 3V Biosciences, Alnylam, and Pfizer Pharmaceuticals. Dr. Harlow has received numerous scientific honors, including election to the National Academy of Sciences in 1993 and the Institute of Medicine in 1999, appointment as Fellow of the American Academy of Arts and Sciences, and recipient of the American Cancer Society's highest award, the Medal of Honor. Dr. Harlow with Dr. David Lane are co-authors of one of the all time best-selling research manuals, Antibodies: A laboratory manual.  Dr. Harlow received his B.S. and M.S. from the University of Oklahoma and his Ph.D. at the Imperial Cancer Research Fund in London in 1982.

The retinoblastoma protein binds to a family of E2F transcription factors.
Authors: Authors: Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K.
Mol Cell Biol
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Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F.
Authors: Authors: Cao L, Faha B, Dembski M, Tsai LH, Harlow E, Dyson N.
Nature
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The retinoblastoma protein is phosphorylated during specific phases of the cell cycle.
Authors: Authors: Buchkovich K, Duffy LA, Harlow E.
Cell
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Complex of simian virus 40 large-T antigen and host 53,000-molecular-weight protein in monkey cells.
Authors: Authors: Harlow E, Pim DC, Crawford LV.
J Virol
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Kinase requirements in human cells: V. Synthetic lethal interactions between p53 and the protein kinases SGK2 and PAK3.
Authors: Authors: Baldwin A, Grueneberg DA, Hellner K, Sawyer J, Grace M, Li W, Harlow E, Munger K.
Proc Natl Acad Sci U S A
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Destabilization of CHK2 by a missense mutation associated with Li-Fraumeni Syndrome.
Authors: Authors: Lee SB, Kim SH, Bell DW, Wahrer DC, Schiripo TA, Jorczak MM, Sgroi DC, Garber JE, Li FP, Nichols KE, Varley JM, Godwin AK, Shannon KM, Harlow E, Haber DA.
Cancer Res
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Tumour-suppressor genes: evolving definitions in the genomic age.
Authors: Authors: Haber D, Harlow E.
Nat Genet
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p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F.
Authors: Authors: Zhu L, Harlow E, Dynlacht BD.
Genes Dev
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Characterization of the retinoblastoma binding proteins RBP1 and RBP2.
Authors: Authors: Fattaey AR, Helin K, Dembski MS, Dyson N, Harlow E, Vuocolo GA, Hanobik MG, Haskell KM, Oliff A, Defeo-Jones D, et al.
Oncogene
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Interaction between human cyclin A and adenovirus E1A-associated p107 protein.
Authors: Authors: Faha B, Ewen ME, Tsai LH, Livingston DM, Harlow E.
Science
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