Eric Fischer, PhD

Assistant Professor of Biological Chemistry and Molecular Pharmacology, Dana-Farber Cancer Institute
Plasticity in binding confers selectivity in ligand-induced protein degradation.
Authors: Authors: Nowak RP, DeAngelo SL, Buckley D, He Z, Donovan KA, An J, Safaee N, Jedrychowski MP, Ponthier CM, Ishoey M, Zhang T, Mancias JD, Gray NS, Bradner JE, Fischer ES.
Nat Chem Biol
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Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK).
Authors: Authors: Powell CE, Gao Y, Tan L, Donovan KA, Nowak RP, Loehr A, Bahcall M, Fischer ES, Jänne PA, George RE, Gray NS.
J Med Chem
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ER Stress Signaling Promotes the Survival of Cancer "Persister Cells" Tolerant to EGFR Tyrosine Kinase Inhibitors.
Authors: Authors: Terai H, Kitajima S, Potter DS, Matsui Y, Quiceno LG, Chen T, Kim TJ, Rusan M, Thai TC, Piccioni F, Donovan KA, Kwiatkowski N, Hinohara K, Wei G, Gray NS, Fischer ES, Wong KK, Shimamura T, Letai A, Hammerman PS, Barbie DA.
Cancer Res
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Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation.
Authors: Authors: Olson CM, Jiang B, Erb MA, Liang Y, Doctor ZM, Zhang Z, Zhang T, Kwiatkowski N, Boukhali M, Green JL, Haas W, Nomanbhoy T, Fischer ES, Young RA, Bradner JE, Winter GE, Gray NS.
Nat Chem Biol
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A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader.
Authors: Authors: Huang HT, Dobrovolsky D, Paulk J, Yang G, Weisberg EL, Doctor ZM, Buckley DL, Cho JH, Ko E, Jang J, Shi K, Choi HG, Griffin JD, Li Y, Treon SP, Fischer ES, Bradner JE, Tan L, Gray NS.
Cell Chem Biol
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Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C.
Authors: Authors: Zeng M, Lu J, Li L, Feru F, Quan C, Gero TW, Ficarro SB, Xiong Y, Ambrogio C, Paranal RM, Catalano M, Shao J, Wong KK, Marto JA, Fischer ES, Jänne PA, Scott DA, Westover KD, Gray NS.
Cell Chem Biol
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pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase.
Authors: Authors: An J, Ponthier CM, Sack R, Seebacher J, Stadler MB, Donovan KA, Fischer ES.
Nat Commun
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Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome.
Authors: Authors: Cavadini S, Fischer ES, Bunker RD, Potenza A, Lingaraju GM, Goldie KN, Mohamed WI, Faty M, Petzold G, Beckwith RE, Tichkule RB, Hassiepen U, Abdulrahman W, Pantelic RS, Matsumoto S, Sugasawa K, Stahlberg H, Thomä NH.
Nature
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Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations.
Authors: Authors: de Wispelaere M, Du G, Donovan KA, Zhang T, Eleuteri NA, Yuan JC, Kalabathula J, Nowak RP, Fischer ES, Gray NS, Yang PL.
Nat Commun
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Structural basis of lenalidomide-induced CK1a degradation by the CRL4(CRBN) ubiquitin ligase.
Authors: Authors: Petzold G, Fischer ES, Thomä NH.
Nature
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