James Hogle, PhD

Edward S. Harkness Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
A Small Covalent Allosteric Inhibitor of Human Cytomegalovirus DNA Polymerase Subunit Interactions.
Authors: Authors: Chen H, Coseno M, Ficarro SB, Mansueto MS, Komazin-Meredith G, Boissel S, Filman DJ, Marto JA, Hogle JM, Coen DM.
ACS Infect Dis
View full abstract on Pubmed
Structure of the Fab-labeled "breathing" state of native poliovirus.
Authors: Authors: Lin J, Lee LY, Roivainen M, Filman DJ, Hogle JM, Belnap DM.
J Virol
View full abstract on Pubmed
Crystal structure of poliovirus 3CD protein: virally encoded protease and precursor to the RNA-dependent RNA polymerase.
Authors: Authors: Marcotte LL, Wass AB, Gohara DW, Pathak HB, Arnold JJ, Filman DJ, Cameron CE, Hogle JM.
J Virol
View full abstract on Pubmed
Kinetic analysis of the effect of poliovirus receptor on viral uncoating: the receptor as a catalyst.
Authors: Authors: Tsang SK, McDermott BM, Racaniello VR, Hogle JM.
J Virol
View full abstract on Pubmed
The poliovirus empty capsid specifically recognizes the poliovirus receptor and undergoes some, but not all, of the transitions associated with cell entry.
Authors: Authors: Basavappa R, Gómez-Yafal A, Hogle JM.
J Virol
View full abstract on Pubmed
Structure of the complex between the Fab fragment of a neutralizing antibody for type 1 poliovirus and its viral epitope.
Authors: Authors: Wien MW, Filman DJ, Stura EA, Guillot S, Delpeyroux F, Crainic R, Hogle JM.
Nat Struct Biol
View full abstract on Pubmed
Three-dimensional structure of a mouse-adapted type 2/type 1 poliovirus chimera.
Authors: Authors: Yeates TO, Jacobson DH, Martin A, Wychowski C, Girard M, Filman DJ, Hogle JM.
EMBO J
View full abstract on Pubmed
Modulation of humoral response to a 12-amino-acid site on the poliovirus virion.
Authors: Authors: Icenogle JP, Minor PD, Ferguson M, Hogle JM.
J Virol
View full abstract on Pubmed
Covalently circularized nanodiscs for studying membrane proteins and viral entry.
Authors: Authors: Nasr ML, Baptista D, Strauss M, Sun ZJ, Grigoriu S, Huser S, Plückthun A, Hagn F, Walz T, Hogle JM, Wagner G.
Nat Methods
View full abstract on Pubmed
An externalized polypeptide partitions between two distinct sites on genome-released poliovirus particles.
Authors: Authors: Lin J, Cheng N, Chow M, Filman DJ, Steven AC, Hogle JM, Belnap DM.
J Virol
View full abstract on Pubmed