James Hogle, PhD
Edward S. Harkness Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Characterization of early steps in the poliovirus infection process: receptor-decorated liposomes induce conversion of the virus to membrane-anchored entry-intermediate particles.
Ab initio phasing of high-symmetry macromolecular complexes: successful phasing of authentic poliovirus data to 3.0 A resolution.
Structural basis of the oligomerization of hepatitis delta antigen.
Authors: Authors: Zuccola HJ, Rozzelle JE, Lemon SM, Erickson BW, Hogle JM.
Structure
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Structure
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Substitutions in the capsids of poliovirus mutants selected in human neuroblastoma cells confer on the Mahoney type 1 strain a phenotype neurovirulent in mice.
Authors: Authors: Couderc T, Guédo N, Calvez V, Pelletier I, Hogle J, Colbère-Garapin F, Blondel B.
J Virol
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J Virol
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Virology. Architecture with a difference.
Three-dimensional structure of poliovirus at 2.9 A resolution.
Five of Five VHHs Neutralizing Poliovirus Bind the Receptor-Binding Site.
Authors: Authors: Strauss M, Schotte L, Thys B, Filman DJ, Hogle JM.
J Virol
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J Virol
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Poliovirus RNA is released from the capsid near a twofold symmetry axis.
Crystal structure of the cytomegalovirus DNA polymerase subunit UL44 in complex with the C terminus from the catalytic subunit. Differences in structure and function relative to unliganded UL44.
Authors: Authors: Appleton BA, Brooks J, Loregian A, Filman DJ, Coen DM, Hogle JM.
J Biol Chem
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J Biol Chem
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A structurally biased combinatorial approach for discovering new anti-picornaviral compounds.
Authors: Authors: Tsang SK, Cheh J, Isaacs L, Joseph-McCarthy D, Choi SK, Pevear DC, Whitesides GM, Hogle JM.
Chem Biol
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Chem Biol
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