James Hogle, PhD

Edward S. Harkness Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Crystal structure of poliovirus 3CD protein: virally encoded protease and precursor to the RNA-dependent RNA polymerase.
Authors: Authors: Marcotte LL, Wass AB, Gohara DW, Pathak HB, Arnold JJ, Filman DJ, Cameron CE, Hogle JM.
J Virol
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Kinetic analysis of the effect of poliovirus receptor on viral uncoating: the receptor as a catalyst.
Authors: Authors: Tsang SK, McDermott BM, Racaniello VR, Hogle JM.
J Virol
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The poliovirus empty capsid specifically recognizes the poliovirus receptor and undergoes some, but not all, of the transitions associated with cell entry.
Authors: Authors: Basavappa R, Gómez-Yafal A, Hogle JM.
J Virol
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Structure of the complex between the Fab fragment of a neutralizing antibody for type 1 poliovirus and its viral epitope.
Authors: Authors: Wien MW, Filman DJ, Stura EA, Guillot S, Delpeyroux F, Crainic R, Hogle JM.
Nat Struct Biol
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Three-dimensional structure of a mouse-adapted type 2/type 1 poliovirus chimera.
Authors: Authors: Yeates TO, Jacobson DH, Martin A, Wychowski C, Girard M, Filman DJ, Hogle JM.
EMBO J
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Modulation of humoral response to a 12-amino-acid site on the poliovirus virion.
Authors: Authors: Icenogle JP, Minor PD, Ferguson M, Hogle JM.
J Virol
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Covalently circularized nanodiscs for studying membrane proteins and viral entry.
Authors: Authors: Nasr ML, Baptista D, Strauss M, Sun ZJ, Grigoriu S, Huser S, Plückthun A, Hagn F, Walz T, Hogle JM, Wagner G.
Nat Methods
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An externalized polypeptide partitions between two distinct sites on genome-released poliovirus particles.
Authors: Authors: Lin J, Cheng N, Chow M, Filman DJ, Steven AC, Hogle JM, Belnap DM.
J Virol
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Characterization of early steps in the poliovirus infection process: receptor-decorated liposomes induce conversion of the virus to membrane-anchored entry-intermediate particles.
Authors: Authors: Tuthill TJ, Bubeck D, Rowlands DJ, Hogle JM.
J Virol
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Ab initio phasing of high-symmetry macromolecular complexes: successful phasing of authentic poliovirus data to 3.0 A resolution.
Authors: Authors: Miller ST, Hogle JM, Filman DJ.
J Mol Biol
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