James Hogle, PhD

Edward S. Harkness Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Structural domains of the poliovirus polyprotein are major determinants for proteolytic cleavage at Gln-Gly pairs.
Authors: Authors: Ypma-Wong MF, Filman DJ, Hogle JM, Semler BL.
J Biol Chem
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An interaction between glutathione and the capsid is required for the morphogenesis of C-cluster enteroviruses.
Authors: Authors: Ma HC, Liu Y, Wang C, Strauss M, Rehage N, Chen YH, Altan-Bonnet N, Hogle J, Wimmer E, Mueller S, Paul AV, Jiang P.
PLoS Pathog
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The human cytomegalovirus UL44 C clamp wraps around DNA.
Authors: Authors: Komazin-Meredith G, Petrella RJ, Santos WL, Filman DJ, Hogle JM, Verdine GL, Karplus M, Coen DM.
Structure
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The cytomegalovirus DNA polymerase subunit UL44 forms a C clamp-shaped dimer.
Authors: Authors: Appleton BA, Loregian A, Filman DJ, Coen DM, Hogle JM.
Mol Cell
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The crystal structure of an unusual processivity factor, herpes simplex virus UL42, bound to the C terminus of its cognate polymerase.
Authors: Authors: Zuccola HJ, Filman DJ, Coen DM, Hogle JM.
Mol Cell
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A pseudo-cell based approach to efficient crystallographic refinement of viruses.
Authors: Authors: Jacobson DH, Hogle JM, Filman DJ.
Acta Crystallogr D Biol Crystallogr
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A mutation in VP4 defines a new step in the late stages of cell entry by poliovirus.
Authors: Authors: Moscufo N, Yafal AG, Rogove A, Hogle J, Chow M.
J Virol
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Engineering a poliovirus type 2 antigenic site on a type 1 capsid results in a chimaeric virus which is neurovirulent for mice.
Authors: Authors: Martin A, Wychowski C, Couderc T, Crainic R, Hogle J, Girard M.
EMBO J
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Mechanism of action and capsid-stabilizing properties of VHHs with an in vitro antipolioviral activity.
Authors: Authors: Schotte L, Strauss M, Thys B, Halewyck H, Filman DJ, Bostina M, Hogle JM, Rombaut B.
J Virol
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Post-imaging fiducial markers aid in the orientation determination of complexes with mixed or unknown symmetry.
Authors: Authors: Bubeck D, Filman DJ, Kuzmin M, Fuller SD, Hogle JM.
J Struct Biol
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