James Hogle, PhD

Edward S. Harkness Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Characterization of Poliovirus Neutralization Escape Mutants of Single-Domain Antibody Fragments (VHHs).
Authors: Authors: Schotte L, Thys B, Strauss M, Filman DJ, Rombaut B, Hogle JM.
Antimicrob Agents Chemother
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The crystal structure of PF-8, the DNA polymerase accessory subunit from Kaposi's sarcoma-associated herpesvirus.
Authors: Authors: Baltz JL, Filman DJ, Ciustea M, Silverman JE, Lautenschlager CL, Coen DM, Ricciardi RP, Hogle JM.
J Virol
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Cryo-electron microscopy reconstruction of a poliovirus-receptor-membrane complex.
Authors: Authors: Bubeck D, Filman DJ, Hogle JM.
Nat Struct Mol Biol
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Is the 135S poliovirus particle an intermediate during cell entry?
Authors: Authors: Huang Y, Hogle JM, Chow M.
J Virol
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Use of the multiple copy simultaneous search (MCSS) method to design a new class of picornavirus capsid binding drugs.
Authors: Authors: Joseph-McCarthy D, Hogle JM, Karplus M.
Proteins
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Poliovirus neutralization by antibodies to internal epitopes of VP4 and VP1 results from reversible exposure of these sequences at physiological temperature.
Authors: Authors: Li Q, Yafal AG, Lee YM, Hogle J, Chow M.
J Virol
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Alteration of amino acid 101 within capsid protein VP-1 changes the pathogenicity of Theiler's murine encephalomyelitis virus.
Authors: Authors: Zurbriggen A, Hogle JM, Fujinami RS.
J Exp Med
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Generation of protein-reactive antibodies by short peptides is an event of high frequency: implications for the structural basis of immune recognition.
Authors: Authors: Niman HL, Houghten RA, Walker LE, Reisfeld RA, Wilson IA, Hogle JM, Lerner RA.
Proc Natl Acad Sci U S A
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Nectin-like interactions between poliovirus and its receptor trigger conformational changes associated with cell entry.
Authors: Authors: Strauss M, Filman DJ, Belnap DM, Cheng N, Noel RT, Hogle JM.
J Virol
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Rapid actin-dependent viral motility in live cells.
Authors: Authors: Vaughan JC, Brandenburg B, Hogle JM, Zhuang X.
Biophys J
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