Johan Paulsson, PhD
Professor of Systems Biology, Harvard Medical School
Fundamental limits on the suppression of molecular fluctuations.
Origin pairing ('handcuffing') as a mode of negative control of P1 plasmid copy number.
Stochastic activation of a DNA damage response causes cell-to-cell mutation rate variation.
Authors: Authors: Uphoff S, Lord ND, Okumus B, Potvin-Trottier L, Sherratt DJ, Paulsson J.
Science
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Science
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Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity.
Authors: Authors: Usui K, Hulleman JD, Paulsson JF, Siegel SJ, Powers ET, Kelly JW.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Noise in a minimal regulatory network: plasmid copy number control.
Constraints on Fluctuations in Sparsely Characterized Biological Systems.
Authors: Authors: Hilfinger A, Norman TM, Vinnicombe G, Paulsson J.
Phys Rev Lett
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Phys Rev Lett
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Effects of molecular memory and bursting on fluctuations in gene expression.
Fluctuations in repressor control: thermodynamic constraints on stochastic focusing.
Bacterial variability in the mammalian gut captured by a single-cell synthetic oscillator.
Authors: Authors: Riglar DT, Richmond DL, Potvin-Trottier L, Verdegaal AA, Naydich AD, Bakshi S, Leoncini E, Lyon LG, Paulsson J, Silver PA.
Nat Commun
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Nat Commun
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Visualization of Periplasmic and Cytoplasmic Proteins with a Self-Labeling Protein Tag.