John Mekalanos, PhD

Adele Lehman Professor of Microbiology and Molecular Genetics, Harvard Medical School
Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling.
Authors: Authors: Chang D, Whiteley AT, Bugda Gwilt K, Lencer WI, Mekalanos JJ, Thiagarajah JR.
Proc Natl Acad Sci U S A
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Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance.
Authors: Authors: Zhou W, Whiteley AT, de Oliveira Mann CC, Morehouse BR, Nowak RP, Fischer ES, Gray NS, Mekalanos JJ, Kranzusch PJ.
Cell
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Generation of reactive oxygen species by lethal attacks from competing microbes.
Authors: Authors: Dong TG, Dong S, Catalano C, Moore R, Liang X, Mekalanos JJ.
Proc Natl Acad Sci U S A
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Quorum-sensing autoinducers resuscitate dormant Vibrio cholerae in environmental water samples.
Authors: Authors: Bari SM, Roky MK, Mohiuddin M, Kamruzzaman M, Mekalanos JJ, Faruque SM.
Proc Natl Acad Sci U S A
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Comparisons of Two Proteomic Analyses of Non-Mucoid and Mucoid Pseudomonas aeruginosa Clinical Isolates from a Cystic Fibrosis Patient.
Authors: Authors: Rao J, Damron FH, Basler M, Digiandomenico A, Sherman NE, Fox JW, Mekalanos JJ, Goldberg JB.
Front Microbiol
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Translocation of a Vibrio cholerae type VI secretion effector requires bacterial endocytosis by host cells.
Authors: Authors: Ma AT, McAuley S, Pukatzki S, Mekalanos JJ.

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New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis.
Authors: Authors: Smith MG, Gianoulis TA, Pukatzki S, Mekalanos JJ, Ornston LN, Gerstein M, Snyder M.
Genes Dev
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Combining anthrax vaccine and therapy: a dominant-negative inhibitor of anthrax toxin is also a potent and safe immunogen for vaccines.
Authors: Authors: Aulinger BA, Roehrl MH, Mekalanos JJ, Collier RJ, Wang JY.
Infect Immun
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A dually active anthrax vaccine that confers protection against both bacilli and toxins.
Authors: Authors: Rhie GE, Roehrl MH, Mourez M, Collier RJ, Mekalanos JJ, Wang JY.
Proc Natl Acad Sci U S A
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Vibrio cholerae-induced cellular responses of polarized T84 intestinal epithelial cells are dependent on production of cholera toxin and the RTX toxin.
Authors: Authors: Fullner KJ, Lencer WI, Mekalanos JJ.
Infect Immun
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