John Mekalanos, PhD
Adele Lehman Professor of Microbiology and Molecular Genetics, Harvard Medical School
Construction of a Vibrio cholerae prototype vaccine strain O395-N1-E1 which accumulates cell-associated cholera toxin B subunit.
A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus.
Authors: Authors: Mougous JD, Cuff ME, Raunser S, Shen A, Zhou M, Gifford CA, Goodman AL, Joachimiak G, Ordoñez CL, Lory S, Walz T, Joachimiak A, Mekalanos JJ.
Science
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Science
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Role of the type III secreted exoenzymes S, T, and Y in systemic spread of Pseudomonas aeruginosa PAO1 in vivo.
CTXphi-independent production of the RS1 satellite phage by Vibrio cholerae.
Authors: Authors: Faruque SM, Kamruzzaman M, Sack DA, Mekalanos JJ, Nair GB.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Transposon-based approaches to identify essential bacterial genes.
Bacterial mucosal vaccines: Vibrio cholerae as a live attenuated vaccine/vector paradigm.
Authors: Authors: Killeen K, Spriggs D, Mekalanos J.
Curr Top Microbiol Immunol
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Curr Top Microbiol Immunol
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Differential regulation of multiple flagellins in Vibrio cholerae.
Safety, immunogenicity, and efficacy of live attenuated Vibrio cholerae O139 vaccine prototype.
Authors: Authors: Coster TS, Killeen KP, Waldor MK, Beattie DT, Spriggs DR, Kenner JR, Trofa A, Sadoff JC, Mekalanos JJ, Taylor DN.
Lancet
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Lancet
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ToxR regulates virulence gene expression in non-O1 strains of Vibrio cholerae that cause epidemic cholera.
Environmental signals controlling expression of virulence determinants in bacteria.