John Mekalanos, PhD

Adele Lehman Professor of Microbiology and Molecular Genetics, Harvard Medical School
Toxin, toxin-coregulated pili, and the toxR regulon are essential for Vibrio cholerae pathogenesis in humans.
Authors: Authors: Herrington DA, Hall RH, Losonsky G, Mekalanos JJ, Taylor RK, Levine MM.
J Exp Med
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Effect of a recA mutation on cholera toxin gene amplification and deletion events.
Authors: Authors: Goldberg I, Mekalanos JJ.
J Bacteriol
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Genetic mapping of toxin regulatory mutations in Vibrio cholerae.
Authors: Authors: Mekalanos JJ, Sublett RD, Romig WR.
J Bacteriol
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CBASS Immunity Uses CARF-Related Effectors to Sense 3'-5'- and 2'-5'-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection.
Authors: Authors: Lowey B, Whiteley AT, Keszei AFA, Morehouse BR, Mathews IT, Antine SP, Cabrera VJ, Kashin D, Niemann P, Jain M, Schwede F, Mekalanos JJ, Shao S, Lee ASY, Kranzusch PJ.
Cell
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A live vaccine rapidly protects against cholera in an infant rabbit model.
Authors: Authors: Hubbard TP, Billings G, Dörr T, Sit B, Warr AR, Kuehl CJ, Kim M, Delgado F, Mekalanos JJ, Lewnard JA, Waldor MK.
Sci Transl Med
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Vibrio cholerae T3SS effector VopE modulates mitochondrial dynamics and innate immune signaling by targeting Miro GTPases.
Authors: Authors: Suzuki M, Danilchanka O, Mekalanos JJ.

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Coupling mutagenesis and parallel deep sequencing to probe essential residues in a genome or gene.
Authors: Authors: Robins WP, Faruque SM, Mekalanos JJ.
Proc Natl Acad Sci U S A
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Type III secretion is essential for the rapidly fatal diarrheal disease caused by non-O1, non-O139 Vibrio cholerae.
Authors: Authors: Shin OS, Tam VC, Suzuki M, Ritchie JM, Bronson RT, Waldor MK, Mekalanos JJ.
mBio
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Effect of phage on the infectivity of Vibrio cholerae and emergence of genetic variants.
Authors: Authors: Zahid MS, Udden SM, Faruque AS, Calderwood SB, Mekalanos JJ, Faruque SM.
Infect Immun
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2,3-butanediol synthesis and the emergence of the Vibrio cholerae El Tor biotype.
Authors: Authors: Yoon SS, Mekalanos JJ.
Infect Immun
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